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The effect of culture medium and carrier on explant culture of human limbal epithelium: A comparison of ultrastructure, keratin profile and gene expression

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F16%3A10330345" target="_blank" >RIV/00216208:11110/16:10330345 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.exer.2016.09.012" target="_blank" >http://dx.doi.org/10.1016/j.exer.2016.09.012</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.exer.2016.09.012" target="_blank" >10.1016/j.exer.2016.09.012</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The effect of culture medium and carrier on explant culture of human limbal epithelium: A comparison of ultrastructure, keratin profile and gene expression

  • Original language description

    Patients with limbal stem cell deficiency (LSCD) often experience pain and photophobia due to recurrent epithelial defects and chronic inflammation of the cornea. Successfully restoring a healthy corneal surface in these patients by transplantation of ex vivo expanded human limbal epithelial cells (LECs) may alleviate these symptoms and significantly improve their quality of life. The clinical outcome of transplantation is known to be influenced by the quality of transplanted cells. Presently, several different protocols for cultivation and transplantation of LECs are in use. However, no consensus on an optimal protocol exists. The aim of this study was to examine the effect of culture medium and carrier on the morphology, staining of selected keratins and global gene expression in ex vivo cultured LECs.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FF - ENT (ie. ear, nose, throat), ophthalmology, dentistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/7F14156" target="_blank" >7F14156: Tissue engineering of genetically competent corneal and conjunctival cells for subsequent grafting in human medicine</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Experimental Eye Research

  • ISSN

    0014-4835

  • e-ISSN

  • Volume of the periodical

    153

  • Issue of the periodical within the volume

    December

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    11

  • Pages from-to

    122-132

  • UT code for WoS article

    000389287700014

  • EID of the result in the Scopus database

    2-s2.0-84994037274