Disease specificity of autoantibodies to cytosolic 5 '-nucleotidase 1A in sporadic inclusion body myositis versus known autoimmune diseases

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F16%3A10333045" target="_blank" >RIV/00216208:11110/16:10333045 - isvavai.cz</a>

Alternative codes found

RIV/00023728:_____/16:N0000023

Result on the web

<a href="http://dx.doi.org/10.1136/annrheumdis-2014-206691" target="_blank" >http://dx.doi.org/10.1136/annrheumdis-2014-206691</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1136/annrheumdis-2014-206691" target="_blank" >10.1136/annrheumdis-2014-206691</a>

Result language

angličtina

Original language name

Disease specificity of autoantibodies to cytosolic 5 '-nucleotidase 1A in sporadic inclusion body myositis versus known autoimmune diseases

Original language description

Objectives The diagnosis of inclusion body myositis (IBM) can be challenging as it can be difficult to clinically distinguish from other forms of myositis, particularly polymyositis (PM). Recent studies have shown frequent presence of autoantibodies directed against cytosolic 5'-nucleotidase 1A (cN-1A) in patients with IBM. We therefore, examined the autoantigenicity and disease specificity of major epitopes of cN-1A in patients with sporadic IBM compared with healthy and disease controls. Methods Serum samples obtained from patients with IBM (n = 238), PM and dermatomyositis (DM) (n = 185), other autoimmune diseases (n = 246), other neuromuscular diseases (n = 93) and healthy controls (n = 35) were analysed for the presence of autoantibodies using immunodominant cN-1A peptide ELISAs. Results Autoantibodies directed against major epitopes of cN-1A were frequent in patients with IBM (37%) but not in PM, DM or non-autoimmune neuromuscular diseases (<5%). Anti-cN-1A reactivity was also observed in some other autoimmune diseases, particularly Sjgren's syndrome (SjS; 36%) and systemic lupus erythematosus (SLE; 20%). Conclusions In summary, we found frequent anti-cN1A autoantibodies in sera from patients with IBM. Heterogeneity in reactivity with the three immunodominant epitopes indicates that serological assays should not be limited to a distinct epitope region. The similar reactivities observed for SjS and SLE demonstrate the need to further investigate whether distinct IBM-specific epitopes exist.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

—

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Annals of the Rheumatic Diseases

ISSN

0003-4967

e-ISSN

—

Volume of the periodical

75

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

696-701

UT code for WoS article

000373403800021

EID of the result in the Scopus database

2-s2.0-84930014705