Development of autoantibodies against muscle-specific FHL1 in severe inflammatory myopathies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023728%3A_____%2F15%3A%230005014" target="_blank" >RIV/00023728:_____/15:#0005014 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/15:10314190
Result on the web
<a href="http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=3&SID=X2dofInb8mHH1Zqt2wZ&page=1&doc=1" target="_blank" >http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=3&SID=X2dofInb8mHH1Zqt2wZ&page=1&doc=1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1172/JCI81031" target="_blank" >10.1172/JCI81031</a>
Alternative languages
Result language
angličtina
Original language name
Development of autoantibodies against muscle-specific FHL1 in severe inflammatory myopathies
Original language description
We show that patients with idiopathic inflammatory myopathies develop autoimmunity to four-and-a-half LIM domain 1 (FHL1), which is a muscle-specific protein. Anti-FHL1 autoantibodies were detected in 25% of IIM patients, while patients with other autoimmune diseases or muscular dystrophies were largely anti-FHL1 negative. Anti-FHL1 reactivity was predictive for muscle atrophy, dysphagia, pronounced muscle fiber damage, and vasculitis. FHL1 showed an altered expression pattern, with focal accumulation in the muscle fibers of autoantibody-positive patients. Immunization of myositis-prone mice with FHL1 aggravated muscle weakness and increased mortality.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Clinical Investigation
ISSN
0021-9738
e-ISSN
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Volume of the periodical
125
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
4612-4624
UT code for WoS article
000365831300026
EID of the result in the Scopus database
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