Serum autoantibodies against hexokinase 1 manifest secondary to diabetic macular edema onset

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F24%3A43927090" target="_blank" >RIV/00216208:11120/24:43927090 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/24:00136124 RIV/65269705:_____/24:00080016 RIV/00179906:_____/24:10481029 RIV/00064173:_____/24:43927090 RIV/00843989:_____/24:E0110998
Result on the web
<a href="https://doi.org/10.1016/j.diabres.2024.111721" target="_blank" >https://doi.org/10.1016/j.diabres.2024.111721</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.diabres.2024.111721" target="_blank" >10.1016/j.diabres.2024.111721</a>

Result language
angličtina
Original language name
Serum autoantibodies against hexokinase 1 manifest secondary to diabetic macular edema onset
Original language description
AIMS: Autoantibodies against hexokinase 1 (HK1) were recently proposed to be associated with diabetic macular edema (DME). We hypothesized that anti-HK1 autoantibodies can be used as DME markers and to predict DME onset. MATERIALS AND METHODS: Serum from patients with 1) DME, 2) diabetes mellitus (DM), 3) allergies or autoimmunities, and 4) control subjects was tested for anti-HK1 and anti-hexokinase 2 (HK2) autoantibodies by immunoblotting. Patients with DM were prospectively followed for up to nine years, and the association of anti-HK1 antibodies with new-onset DME was evaluated. The vitreous humor was also tested for autoantibodies. RESULTS: Among patients with DME, 32 % were positive for anti-HK1 autoantibodies (42 % of those with underlying type 1 DM and 31 % of those with underlying type 2 DM), and 12 % were positive for anti-HK2 autoantibodies, with only partial overlap of these two groups of patients. Anti-HK1 positive were also 7 % of patients with DM, 6 % of patients with allergies and autoimmunities, and 3 % of control subjects. The latter three groups were anti-HK2 negative. Only one of seven patients with DM who were initially anti-HK1 positive developed DME. CONCLUSIONS: Anti-HK1 autoantibodies can be used as DME markers but fail to predict DME onset.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)

Project
<a href="/en/project/TP01010040" target="_blank" >TP01010040: The support of the process of commercialisation of research and development results at Charles University II</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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