Gut Virome Sequencing in Children With Early Islet Autoimmunity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10294477" target="_blank" >RIV/00216208:11130/15:10294477 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/15:10294477
Result on the web
<a href="http://dx.doi.org/10.2337/dc14-2490" target="_blank" >http://dx.doi.org/10.2337/dc14-2490</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2337/dc14-2490" target="_blank" >10.2337/dc14-2490</a>
Alternative languages
Result language
angličtina
Original language name
Gut Virome Sequencing in Children With Early Islet Autoimmunity
Original language description
OBJECTIVEThis study used next-generation sequencing (NGS) technologies to characterize the gut virome at the onset of islet autoimmunity.RESEARCH DESIGN AND METHODSWe conducted a case-control study nested within the Finnish Diabetes Prediction and Prevention (DIPP) cohort. The stool virome in 19 case children, who turned islet autoantibody positive before the age of 2 years and later developed clinical type 1 diabetes, and 19 tightly matched control subjects was analyzed using NGS performed from stool samples collected 3, 6, and 9 months before the onset of islet autoimmunity. Human virus findings were verified using real-time PCR.RESULTSOne or more human viruses were present in 10.4% and bacteriophages were in 54% of the samples. The virome composition showed no association with islet autoimmunity. NGS was less sensitive and specific than real-time PCR.CONCLUSIONSThe present data suggest no dramatic changes in the gut virome shortly before the emergence of islet autoimmunity and empha
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FG - Paediatrics
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT11465" target="_blank" >NT11465: Selected picornaviruses in the pathogenesis of islet autoimmunity and type 1 diabetes</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Diabetes Care
ISSN
0149-5992
e-ISSN
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Volume of the periodical
38
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
4
Pages from-to
930-933
UT code for WoS article
000353505600037
EID of the result in the Scopus database
2-s2.0-84939250362