Eukaryotic viruses in the faecal virome at the onset of type 1 diabetes: a study from four geographically distant African and Asian countries

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F21%3A10426105" target="_blank" >RIV/00216208:11130/21:10426105 - isvavai.cz</a>

Alternative codes found

RIV/00064203:_____/21:10426105

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=KydxIbI3RQ" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=KydxIbI3RQ</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/pedi.13207" target="_blank" >10.1111/pedi.13207</a>

Result language

angličtina

Original language name

Eukaryotic viruses in the faecal virome at the onset of type 1 diabetes: a study from four geographically distant African and Asian countries

Original language description

Studies of the faecal virome in type 1 diabetes (T1D) have been limited to populations of Europe and the USA. We therefore sought to characterize the stool virome in children after onset of T1D and in matched control subjects from four geographically distant African and Asian countries. Samples of stool were collected from 73 children and adolescents shortly after T1D onset (Azerbaijan 19, Jordan 20, Nigeria 14, Sudan 20) and 105 matched control subjects of similar age and locale. Metagenomic sequencing of the DNA and RNA virome was performed, and virus positivity was defined as more than 0.001% of reads of the sample. Selected viruses were also quantified using real-time PCR. Conditional logistic regression was used to model associations with eukaryotic virus positivity. Signals of 387 different viral species were detected; at least one eukaryotic virus was detected in 71% case and 65% control samples. Neither of observed eukaryotic virus species or genera differed in frequency between children with T1D and controls. There was a suggestive association of the total count of different viral genera per sample between cases (1.45 genera) and controls (1.10 genera, OR 1.24, 95%CI 0.98-1.57), and an unplanned subanalysis suggested marginally more frequent endogenous retrovirus signal in cases (in 28.8% vs. in 8.6% controls, OR = 4.55, 95%CI 1.72-12). No clear and consistent association with T1D was observed in the faecal viromes from four distant non-European populations. The finding of borderline associations of human endogenous retroviruses merits further exploration. This article is protected by copyright. All rights reserved.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

<a href="/en/project/NV15-31426A" target="_blank" >NV15-31426A: Childhood-onset diabetes in sub-Saharan Africa: genetic and virological findings in Nigeria, and their comparison to European populations</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Pediatric Diabetes

ISSN

1399-543X

e-ISSN

—

Volume of the periodical

22

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

558-566

UT code for WoS article

000637511300001

EID of the result in the Scopus database

2-s2.0-85103632006