Long-Term Effect of Adrenalectomy on Cardiovascular Remodeling in Patients With Pheochromocytoma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10333494" target="_blank" >RIV/00216208:11110/17:10333494 - isvavai.cz</a>
Alternative codes found
RIV/00023001:_____/17:00075957 RIV/00064165:_____/17:10333494
Result on the web
<a href="http://dx.doi.org/10.1210/jc.2016-2422" target="_blank" >http://dx.doi.org/10.1210/jc.2016-2422</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1210/jc.2016-2422" target="_blank" >10.1210/jc.2016-2422</a>
Alternative languages
Result language
angličtina
Original language name
Long-Term Effect of Adrenalectomy on Cardiovascular Remodeling in Patients With Pheochromocytoma
Original language description
Catecholamines may contribute to the accumulation of collagen fibers and extracellular matrix in the arterial and myocardial wall due to various mechanisms. Reversibility of this process has not been studied on both structures simultaneously. OBJECTIVE: This study aimed to clarify the long-term effect of catecholamines' excess normalization on carotid and myocardial wall changes in patients with pheochromocytoma or functional paraganglioma (PHEO) after tumor removal. Design, Settings and Patients: Carotid intima-media thickness (IMT) and left ventricle (LV) mass index were studied in 50 patients with PHEO before tumor removal and 5 years after tumor removal and in 50 blood pressure- and age-matched essential hypertensive patients (EH) before follow-up and after 5 years of follow-up. MAIN OUTCOME MEASURES: Common carotid IMT (CCA-IMT) and LV mass indexed to the lean body mass (LBM). RESULTS: Elimination of catecholamine excess in the PHEO group resulted in a significant decrease in CCA-IMT and LV mass index from 0.86 +- 0.17 to 0.83 +- 0.18 mm (P <0.05) and from 3.2 +- 0.9 to 2.9 +- 0.9 g/LBM (P <0.001), respectively. In contrast, CCA-IMT and LV mass index increased significantly from 0.78 +- 0.14 to 0.81 +- 0.15 mm (P <0.05) and from 3.1 +- 0.7 to 3.2 +- 0.6 g/LBM (P <0.05), respectively, in patients with essential hypertension. CONCLUSION: In patients with PHEO, carotid IMT and LV mass index can significantly regress after the tumor removal, in contrast to the impairment of these parameters in patients with EH during the same long-term period.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)
Result continuities
Project
<a href="/en/project/NV16-30345A" target="_blank" >NV16-30345A: Pheochromocytoma as a model of chronic activation of the stress axis in the pathogenesis of metabolic disorders</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
The Journal of Clinical Endocrinology & Metabolism
ISSN
0021-972X
e-ISSN
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Volume of the periodical
102
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
1208-1217
UT code for WoS article
000402195300013
EID of the result in the Scopus database
2-s2.0-85017285300