Thyroid in pregnancy: From physiology to screening

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10359035" target="_blank" >RIV/00216208:11110/17:10359035 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/17:10359035

Result on the web

<a href="http://dx.doi.org/10.1080/10408363.2016.1269309" target="_blank" >http://dx.doi.org/10.1080/10408363.2016.1269309</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/10408363.2016.1269309" target="_blank" >10.1080/10408363.2016.1269309</a>

Result language

angličtina

Original language name

Thyroid in pregnancy: From physiology to screening

Original language description

Thyroid hormones are crucial for the growth and maturation of many target tissues, especially the brain and skeleton. During critical periods in the first trimester of pregnancy, maternal thyroxine is essential for fetal development as it supplies thyroid hormone-dependent tissues. The ontogeny of mature thyroid function involves organogenesis, and maturation of the hypothalamus, pituitary and the thyroid gland; and it is almost complete by the 12th-14th gestational week. In case of maternal hypothyroidism, substitution with levothyroxine must be started in early pregnancy. After the 14th gestational week, fetal brain development may already be irreversibly affected by lack of thyroid hormones. The prevalence of manifest hypothyroidism in pregnancy is about 0.3-0.5%. The prevalence of subclinical hypothyroidism varies between 4 and 17%, strongly depending on the definition of the upper TSH cutoff limit. Hyperthyroidism occurs in 0.1-1% of all pregnancies. Positivity for antibodies against thyroid peroxidase (TPOAb) is common in women of childbearing age with an incidence rate of 5.1-12.4%. TPOAb-positivity may be regarded as a manifestation of a general autoimmune state which may alter the fertilization and implantation processes or cause early missed abortions. Women positive for TPOAb are at a significant risk of developing hypothyroidism during pregnancy and postpartum.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

<a href="/en/project/NT11277" target="_blank" >NT11277: Standardization of dynamic tests of hypocorticalism</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Critical Reviews in Clinical Laboratory Sciences

ISSN

1040-8363

e-ISSN

—

Volume of the periodical

54

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

15

Pages from-to

102-116

UT code for WoS article

000395559000003

EID of the result in the Scopus database

2-s2.0-85014944070