The prevalence of maternal hypothyroidism in first trimester screening from 11 to 14 weeks of gestation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F19%3AA2001ZRG" target="_blank" >RIV/61988987:17110/19:A2001ZRG - isvavai.cz</a>

Result on the web

<a href="https://biomed.papers.upol.cz/artkey/bio-201903-0012_the-prevalence-of-maternal-hypothyroidism-in-first-trimester-screening-from-11-to-14-weeks-of-gestation.php" target="_blank" >https://biomed.papers.upol.cz/artkey/bio-201903-0012_the-prevalence-of-maternal-hypothyroidism-in-first-trimester-screening-from-11-to-14-weeks-of-gestation.php</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2018.063" target="_blank" >10.5507/bp.2018.063</a>

Result language

angličtina

Original language name

The prevalence of maternal hypothyroidism in first trimester screening from 11 to 14 weeks of gestation

Original language description

Aim. The aim of this study was to determine the prevalence of maternal hypothyroidism in the first trimester from 11 to 14 weeks of gestation according to the American Thyroid Association (ATA) guidelines from 2017 and to compare the rates for singleton and twin pregnancies. Methods. A total of 4965 consecutive Caucasian singleton pregnancies and 109 Caucasian twin pregnancies were included in the investigation. Patients with a history of thyroid gland disorder were excluded. Subclinical maternal hypothyroidism was defined as a thyroid stimulating hormone (TSH) concentration above the 97.5th percentile and free thyroxine (fT4) within the range of a reference population of women at 11-14 weeks of gestation. Overt maternal hypothyroidism was defined as a TSH concentration above the 97.5th percentile and an fT4 below the 2.5th percentile of the reference population. TSH, fT4, and anti thyroid peroxidase antibody (TPOAb) were measured by immunochemiluminescent assays on an 16200 Abbott Architect analyzer. Results. The prevalence of hypothyroidism for twin pregnancies was no higher than that for singleton pregnancies; 6.42% (7/109) vs. 5.32% (264/4965), respectively; P=0.61. All twin pregnancies were subclinical. Singleton hypothyroid pregnancies included 4.91% (244 cases) of subclinical and 0.41% (20 cases) of overt hypothyroidism. The prevalence of TPOAb positive hypothyroid women for twin pregnancies and singleton pregnancies was 71% (5/7) vs. 52% (137/264 cases), respectively but the differences were not statistically significant; P=0.31. Conclusion. Each first trimester screening center should establish its TSH and fT4 reference ranges. Our center had higher upper reference limits of TSH than that of the universally fixed limit of 2.5 mU/L, which led to a lower measured prevalence of maternal hypothyroidism. A large number of hypothyroid women were TPOAb positive.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30104 - Pharmacology and pharmacy

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bio Pap Med Fac Univerzita Palackého Olomouc

ISSN

1213-8118

e-ISSN

1804-7521

Volume of the periodical

163

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

3

Pages from-to

265-268

UT code for WoS article

000489991000012

EID of the result in the Scopus database

2-s2.0-85072707018