Maternal thyroid-stimulating hormone reference ranges for first trimester screening from 11 to 14 weeks of gestation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F18%3AA2001S32" target="_blank" >RIV/61988987:17110/18:A2001S32 - isvavai.cz</a>

Result on the web

<a href="https://biomed.papers.upol.cz/pdfs/bio/2019/03/12.pdf" target="_blank" >https://biomed.papers.upol.cz/pdfs/bio/2019/03/12.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jcla.22405" target="_blank" >10.1002/jcla.22405</a>

Result language

angličtina

Original language name

Maternal thyroid-stimulating hormone reference ranges for first trimester screening from 11 to 14 weeks of gestation

Original language description

BackgroundTo establish maternal thyroid-stimulating hormone (TSH) reference ranges for first trimester screening from 11 + 0 to 13 + 6 weeks of gestation.MethodsA total of 10 592 singleton and 201 twin consecutive Caucasian pregnant women who underwent simultaneously prenatal first trimester Down's syndrome screening and thyroid function screening from January 2010 to November 2017 were included in the study. Women with positive antithyroid peroxidase antibody (TPOAb) and positive personal history of thyroid disease were previously excluded. TSH was measured by immunochemiluminescent assay on ci 16200 Abbott Architect analyzer. Nonparametric percentile method (also known as CLSI C28.A3) was used for the determination of reference ranges.ResultsWe established reference ranges of TSH for the period of gestation from 11 + 0 to 13 + 6 weeks of pregnancy as 0.16-3.43 mU/L for singleton Caucasian pregnancies and 0.02-2.95 mU/L for twin Caucasian pregnancies. The median (IQR) of TSH for singleton pregnancies was higher than that for twin pregnancies (1.25 mU/L (0.83-1.81) vs 0.84 (0.37-1.47), respectively; P &lt; .0001).ConclusionsEach first trimester screening center should be aware of which type of immunoassay their laboratory uses. TSH reference ranges in women during the first trimester of pregnancy are lower than those for general population. Twin pregnancies have lower TSH than singleton pregnancies.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Clinical Laboratory Analysis

ISSN

0887-8013

e-ISSN

1098-2825

Volume of the periodical

163

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

4

Pages from-to

265-268

UT code for WoS article

000438900600004

EID of the result in the Scopus database

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