Genetic Alzheimer Disease and Sporadic Dementia With Lewy Bodies: A Comorbidity Presenting as Primary Progressive Aphasia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10359493" target="_blank" >RIV/00216208:11110/17:10359493 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/17:43913106 RIV/00023884:_____/12:00007491 RIV/00064190:_____/17:N0000024 RIV/00064165:_____/17:10359493
Result on the web
<a href="http://dx.doi.org/10.1097/WNN.0000000000000116" target="_blank" >http://dx.doi.org/10.1097/WNN.0000000000000116</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/WNN.0000000000000116" target="_blank" >10.1097/WNN.0000000000000116</a>
Alternative languages
Result language
angličtina
Original language name
Genetic Alzheimer Disease and Sporadic Dementia With Lewy Bodies: A Comorbidity Presenting as Primary Progressive Aphasia
Original language description
We report a 44-year-old woman, with a family history of early-onset dementia, presenting with primary progressive aphasia. This clinically variable syndrome has multiple underlying pathologies, and correlations between clinical manifestations and postmortem neuropathologic findings are controversial. Our patient suffered worsening language impairment with major word-finding difficulties but preserved comprehension. She also developed episodic memory impairment. Her condition progressed to dementia with behavioral changes. Magnetic resonance imaging showed early left perisylvian and bitemporal atrophy. The patient died shortly afterward from colon cancer. Neuropathologic examination revealed advanced early-onset Alzheimer and Lewy body disease, plus a clinically nonrelevant metastasis of her colon cancer in her left parietal lobe. Genetic examination revealed a p.Glu184Asp mutation in the presenilin1 gene. Our findings confirm the importance of a thorough appreciation for the clinical and neuropathologic correlations in patients with atypical neurodegenerative dementias.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cognitive and Behavioral Neurology
ISSN
1543-3633
e-ISSN
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Volume of the periodical
30
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
23-29
UT code for WoS article
000397972400005
EID of the result in the Scopus database
2-s2.0-85017386175