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Replication of SNP associations with keratoconus in a Czech cohort

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10360681" target="_blank" >RIV/00216208:11110/17:10360681 - isvavai.cz</a>

  • Alternative codes found

    RIV/68407700:21230/17:00307680 RIV/00216208:11130/17:10360681 RIV/00064203:_____/17:10360681 RIV/00064165:_____/17:10360681

  • Result on the web

    <a href="http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172365" target="_blank" >http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172365</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1371/journal.pone.0172365" target="_blank" >10.1371/journal.pone.0172365</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Replication of SNP associations with keratoconus in a Czech cohort

  • Original language description

    Introduction Keratoconus is a relatively frequent disease leading to severe visual impairment. Existing therapies are imperfect and clinical management may benefit from improved understanding of mechanisms leading to this disease. We aim to investigate the replication of 11 single nucleotide polymorphisms (SNPs) with keratoconus. Methods SNPs from loci previously found in association with keratoconus were genotyped in 165 keratoconus cases of Caucasian Czech origin (108 males and 57 females) and 193 population and gender-matched controls. They included rs1536482 (COL5A1), rs4839200 (KCND3), rs757 219 and rs214884 (IMMP2L), rs1328083 and rs1328089 (DAOA), rs2721051 (FOXO1), rs489 4535 (FNDC3B), rs4954218 (MAP3K19, RAB3GAP1), rs9938149 (ZNF469) and rs1324183 (MPDZ). A case-control association analysis was assessed using Fisher&apos;s exact tests. Results The strongest association was found for rs1324183 (allelic test OR = 1.58; 95% CI, 1.10 - 2.24, p = 0.01). Statistically significant values were also obtained for rs2721051 (allelic test OR = 1.72; 95% CI, 1.07 - 2.77, p = 0.025) and rs4954218 (allelic test OR = 1.53; 95% CI, 1.01 - 2.34; p = 0.047) which showed an opposite effect direction compared to previously reported one. Conclusion Independent replication of association between two SNPs and keratoconus supports the association of these loci with the risks for the disease development, while the effect of rs4954218 warrants further investigation. Understanding the role of the genetic factors

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10600 - Biological sciences

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    PLoS One

  • ISSN

    1932-6203

  • e-ISSN

  • Volume of the periodical

    12

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    7

  • Pages from-to

  • UT code for WoS article

    000394424500125

  • EID of the result in the Scopus database

    2-s2.0-85012960751