Combination of dual-phase and dual-tracer SPECT/CT imaging with voxel-based subtraction in the assessment of normocalcemic primary hyperparathyroidism in patients with osteoporosis: a pilot study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10361051" target="_blank" >RIV/00216208:11110/17:10361051 - isvavai.cz</a>

Alternative codes found

RIV/00064203:_____/17:10361051 RIV/00023728:_____/17:N0000024 RIV/00064165:_____/17:10361051

Result on the web

<a href="http://www.ijcem.com/files/ijcem0052090.pdf" target="_blank" >http://www.ijcem.com/files/ijcem0052090.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Combination of dual-phase and dual-tracer SPECT/CT imaging with voxel-based subtraction in the assessment of normocalcemic primary hyperparathyroidism in patients with osteoporosis: a pilot study

Original language description

Objective: We hypothesized that parathyroid (PT) scintigraphy could be clinically valid in identifying patients, indicated for parathyroidectomy, presenting with consistently elevated PTH and normal serum calcium concentrations. Methods: The parathyroid was examined using Tc-99m-MIBI and (TcO4)-Tc-99m SPECT imaging in 75 patients with a BMD &lt;= -2.5 T (lumbar spine, proximal femur, or distal one-third of the radius) with concomitantly elevated serum PTH concentration. Results: After excluding patients with secondary hyperparathyroidism, PT scintigraphy indicated the presence of an adenoma in all patients (32) with elevated serum PTH and calcium concentrations. After parathyroidectomy, PT adenoma was confirmed in all surgically treated patients (29). The predictive positive value of PT scintigraphy was 87%. PT scintigraphy indicated the presence of an adenoma in 26/34 patients with elevated serum PTH and normal calcium concentrations. Of these patients, 12 were indicated for parathyroidectomy; PT adenoma was found in all cases. In these patients, the predictive positive value was 85%. In 8 patients with increased PTH and normal serum calcium, scintigraphy did not reveal an enlarged PT. In these patients, serum PTH was significantly lower compared to patients with increased calcium and PTH. Conclusion: The combined dual-phase/dual-tracer SPECT imaging method, including low-dose CT, improves the identification of pathological parathyroid glands and is therefore suitable for presurgical detection of both typical primary hyperparathyroidism and normocalcemic primary hyperparathyroidism. The method should be of value for better management of the increasing number of cases seen in subspecialty metabolic bone practices.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30224 - Radiology, nuclear medicine and medical imaging

Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Clinical and Experimental Medicine

ISSN

1940-5901

e-ISSN

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Volume of the periodical

10

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

9518-9525

UT code for WoS article

000404534900103

EID of the result in the Scopus database

2-s2.0-85021366552