Prevalence and Risk Factors of Osteoporosis in Postmenopausal Women with Type 2 Diabetes Mellitus

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10363889" target="_blank" >RIV/00216208:11110/17:10363889 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/17:10363889

Result on the web

<a href="https://cejph.szu.cz/pdfs/cjp/2017/01/01.pdf" target="_blank" >https://cejph.szu.cz/pdfs/cjp/2017/01/01.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.21101/cejph.a4717" target="_blank" >10.21101/cejph.a4717</a>

Result language

angličtina

Original language name

Prevalence and Risk Factors of Osteoporosis in Postmenopausal Women with Type 2 Diabetes Mellitus

Original language description

Objective: Patients with type 2 diabetes (T2DM) are at increased risk of fractures. The aim of this study is to analyze the prevalence and risk factors of osteoporosis and osteoporosis related fractures in postmenopausal women with T2DM. Methods:A total of 112 postmenopausal women with T2DM and 171 control nondiabetic women received a standardized questionnaire on osteoporosis risk factors, and were evaluated for bone mineral density (BMD, by using a dual energy X-ray absorptiometry), biochemical markers of bone and glucose metabolism, soluble receptor for advanced glycation end products (sRAGE) and its gene polymorphisms (rs1800625 or rs2070600). Results: In T2DM patients the prevalence of osteoporosis was 25% and low trauma vertebral (Vfx) and non-vertebral fractures were found in 8% and 19% women, respectively. When compared between subjects with and without fractures, there were no significant differences in BMD at any site between the groups, except for distal radius, which was significantly lower in T2DM women with Vfx (p &lt;0.05 vs.non-fractured without osteoporosis). We found no associations between bone and glucose metabolism variables, sRAGE and BMD. No significant differences were observed in sRAGE levels according to their rs1800625, rs 2070600 genotype or fracture prevalence. Serum osteocalcin was significantly lower in T2DM women (p &lt;0.01 vs. controls) and in T2DM women with Vfx (p &lt;0.05) vs. non-fractured without osteoporosis. T2DM women with low daily walking activity (&lt;2 h daily) had significantly higher serum sclerostin levels (p &lt;0.05 vs. those who were walking &gt; 2 h daily). Conclusion: Diabetes-specific parameters as well as RAGE polymorphisms did not associate with BMD or fractures in T2DM postmenopausal women. Lower levels of osteocalcin, namely in those with Vfx and higher sclerostin levels in those with low daily walking activity suggest lower bone remodeling and/or decreased bone quality in T2DM.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

<a href="/en/project/NT11335" target="_blank" >NT11335: Bone metabolism in patients with type 2 diabetes mellitus: role of the receptor for advanced glycation end products (RAGE) and its gene polymorphism</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Central European Journal of Public Health

ISSN

1210-7778

e-ISSN

—

Volume of the periodical

25

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

8

Pages from-to

3-10

UT code for WoS article

000400953400001

EID of the result in the Scopus database

2-s2.0-85021855523