Body composition is associated with bone and glucose metabolism in postmenopausal women with Type 2 diabetes mellitus

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10366936" target="_blank" >RIV/00216208:11110/17:10366936 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/17:10366936

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/66/66_99.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/66/66_99.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Body composition is associated with bone and glucose metabolism in postmenopausal women with Type 2 diabetes mellitus

Original language description

Type 2 diabetes mellitus (T2DM) is associated with increased fracture risk; the underlying mechanism remains unexplained. This study aimed to investigate the relationships between body composition and bone and glucose metabolism in postmenopausal women with T2DM. Dual-energy X-ray absorptiometry was used to measure bone mineral density (BMD) and body composition. A total of 68 postmenopausal women with T2DM and 71 controls were eligible for the study. In contrast to normal BMD in T2DM, a similar prevalence of lowtrauma fractures was observed in both groups. T2DM women had significantly higher Trunk fat% and A/G ratio and significantly lower Legs LM% and Legs FM%. Legs LM% was significantly lower in fractured T2DM group and negatively correlated with glycaemia and HbA1c (p&lt;0.01). Serum osteocalcin was significantly lower in T2DM and inversely correlated with FM%, Trunk FM% and A/G ratio (p &lt; 0.01) and positively correlated with Legs FM% and total LM% (p &lt;0.05). In conclusion, abdominal obesity and decrease in muscle mass may contribute to low bone formation in T2DM women. Further research is needed to unravel underlying pathophysiological mechanisms and to determine whether maintenance of muscle mass, especially in the lower extremities and/or reduction of central fat mass can prevent fractures.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

<a href="/en/project/NT11335" target="_blank" >NT11335: Bone metabolism in patients with type 2 diabetes mellitus: role of the receptor for advanced glycation end products (RAGE) and its gene polymorphism</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

66

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

13

Pages from-to

99-111

UT code for WoS article

000398620000010

EID of the result in the Scopus database

2-s2.0-85017129434