Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG)

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10364070" target="_blank" >RIV/00216208:11110/17:10364070 - isvavai.cz</a>

Alternative codes found

RIV/00064190:_____/17:N0000053

Result on the web

<a href="http://dx.doi.org/10.1093/jnen/nlx041" target="_blank" >http://dx.doi.org/10.1093/jnen/nlx041</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/jnen/nlx041" target="_blank" >10.1093/jnen/nlx041</a>

Result language

angličtina

Original language name

Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG)

Original language description

Aging-related tau astrogliopathy (ARTAG) is a recently introduced terminology. To facilitate the consistent identification of ARTAG and to distinguish it from astroglial tau pathologies observed in the primary frontotemporal lobar degeneration tauopathies we evaluated how consistently neuropathologists recognize (1) different astroglial tau immunoreactivities, including those of ARTAG and those associated with primary tauopathies (Study 1); (2) ARTAG types (Study 2A); and (3) ARTAG severity (Study 2B). Microphotographs and scanned sections immunostained for phosphorylated tau (AT8) were made available for download and preview. Percentage of agreement and kappa values with 95% confidence interval (CI) were calculated for each evaluation. The overall agreement for Study 1 was &gt; 60% with a kappa value of 0.55 (95% CI 0.433-0.645). Moderate agreement (&gt; 90%, kappa 0.48, 95% CI 0.457-0.900) was reached in Study 2A for the identification of ARTAG pathology for each ARTAG subtype (kappa 0.37-0.72), whereas fair agreement (kappa 0.40, 95% CI 0.341-0.445) was reached for the evaluation of ARTAG severity. The overall assessment of ARTAG showed moderate agreement (kappa 0.60, 95% CI 0.534-0.653) among raters. Our study supports the application of the current harmonized evaluation strategy for ARTAG with a slight modification of the evaluation of its severity.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30109 - Pathology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Neuropathology &amp; Experimental Neurology

ISSN

0022-3069

e-ISSN

—

Volume of the periodical

76

Issue of the periodical within the volume

7

Country of publishing house

US - UNITED STATES

Number of pages

15

Pages from-to

605-619

UT code for WoS article

000404908200007

EID of the result in the Scopus database

2-s2.0-85020517699