A simulation of loading doses for vancomycin continuous infusion regimens in intensive care

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10364155" target="_blank" >RIV/00216208:11110/17:10364155 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1080/23744235.2017.1328741" target="_blank" >http://dx.doi.org/10.1080/23744235.2017.1328741</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/23744235.2017.1328741" target="_blank" >10.1080/23744235.2017.1328741</a>

Result language
angličtina
Original language name
A simulation of loading doses for vancomycin continuous infusion regimens in intensive care
Original language description
Background: Delayed achievement of target vancomycin serum concentrations may adversely affect clinical outcomes. The objective of this retrospective study was to compare the prediction accuracy of different body weight descriptors for volume of distribution and to propose an optimal loading dose (LD) for continuous infusion regimens in adults.Methods: Pharmacokinetic variables were computed using one-compartmental analysis. Simulated LDs of vancomycin were evaluated for each patient.Results: Volume of distribution, clearance, and half-life median values (interquartile range) for vancomycin in the study population (n = 30) were 0.45 (0.39-0.61) L.kg(-1), 0.026 (0.015-0.040) L.h(-1).kg(-1), and 10.3 (7.7-21.3) h, respectively. The observed volume of distribution was better predicted by total body weight (TBW) than by the ideal body weight or the adjusted body weight.Conclusions: An LD of 10.7 mg per kg TBW was optimal in our study population. Using this LD, 17.9% of simulated vancomycin serum levels were just below the therapeutic range, only 10.7% concentrations exceeded the target range and no concentration was toxic. The use of a LD would lead to reduced median time to reach target concentrations from 17 to 1h.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30104 - Pharmacology and pharmacy

Project
—
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)