Leptomeningeal contrast enhancement is associated with progression of cortical atrophy in MS: A retrospective, pilot, observational longitudinal study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10364305" target="_blank" >RIV/00216208:11110/17:10364305 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/17:10364305

Result on the web

<a href="http://dx.doi.org/10.1177/1352458516678083" target="_blank" >http://dx.doi.org/10.1177/1352458516678083</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1177/1352458516678083" target="_blank" >10.1177/1352458516678083</a>

Result language

angličtina

Original language name

Leptomeningeal contrast enhancement is associated with progression of cortical atrophy in MS: A retrospective, pilot, observational longitudinal study

Original language description

Background: Leptomeningeal contrast enhancement (LM CE) has been recently described in multiple sclerosis (MS) patients as a potential in vivo marker of cortical pathology. Objectives: To investigate the association of LM CE and development of cortical atrophy in 50 MS patients (27 relapsing-remitting (RR) and 23 secondary-progressive (SP)) followed for 5years. Methods: The presence and number of LM CE foci were assessed only at the 5-year follow-up using three-dimensional (3D) fluid-attenuated inversion recovery magnetic resonance imaging (MRI) sequence obtained 10minutes after single dose of gadolinium injection on 3T scanner. The percentage change in whole brain, cortical and deep gray matter (GM) volumes, and lesion volume (LV) was measured between baseline and the 5-year follow-up. Results: In total, 25 (50%) of MS patients had LM CE at the 5-year follow-up. Significantly more SPMS patients (12, 85.7%) had multiple LM CE foci, compared to those with RRMS (2, 18.2%) (p=0.001). MS patients with LM CE showed significantly greater percentage decrease in total GM (-3.6% vs -2%, d=0.80, p=0.006) and cortical (-3.4% vs -1.8%, d=0.84, p=0.007) volumes and greater percentage increase in ventricular cerebrospinal fluid (vCSF) volume (22.8% vs 9.9%, d=0.90, p=0.003) over the follow-up, compared to those without. Conclusion: In this retrospective, pilot, observational longitudinal study, the presence of LM CE was associated with progression of cortical atrophy over 5years.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30224 - Radiology, nuclear medicine and medical imaging

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Multiple Sclerosis Journal

ISSN

1352-4585

e-ISSN

—

Volume of the periodical

23

Issue of the periodical within the volume

10

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

1336-1345

UT code for WoS article

000407918800008

EID of the result in the Scopus database

2-s2.0-85027855103