The effect of the colostral cells on gene expression of cytokines in cord blood cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10364684" target="_blank" >RIV/00216208:11110/17:10364684 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s12223-017-0519-6" target="_blank" >http://dx.doi.org/10.1007/s12223-017-0519-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12223-017-0519-6" target="_blank" >10.1007/s12223-017-0519-6</a>

Result language

angličtina

Original language name

The effect of the colostral cells on gene expression of cytokines in cord blood cells

Original language description

Beneficial effect of maternal milk is acknowledged, but there is still question whether maternal milk from allergic mother is as good as from healthy one. In our study, we have assayed the effect of cells from colostrum of healthy and allergic mothers on gene expression of cytokines in cord blood cells of newborns of healthy and allergic mothers. Cytokines typical for Th1 (IL-2, IFN-gamma), Th2 (IL-4, IL-13), Tregs (IL-10, TGF-beta), and IL-8 were followed. We were not able to detect significant influence of colostral cells on gene expression of cytokines in cord blood after 2-day coculture using Transwell system. There was no difference in gene expression of cytokines in nonstimulated cord blood cells of newborns of healthy and allergic mothers, but generally increased gene expression of cytokines except IL-10 and TGF-beta after polyclonal stimulation was detected in cord blood cells of children of allergic mothers. There was no difference in IL-10 expression in stimulated cord blood cells of children of healthy and allergic mothers. Gene expression of TGF-beta was even decreased in stimulated cord blood cells of children of allergic mothers in comparison to healthy ones. We have not observed difference in the capacity of colostral cells of healthy and allergic mothers to influence gene expression of cytokines in cord blood cells, but we have described difference in the reactivity of cord blood cells between children of allergic and healthy mothers.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30102 - Immunology

Project

<a href="/en/project/NV15-26877A" target="_blank" >NV15-26877A: Effect of early postnatal colonisation of newborns by E. coli on allergy incidence, selected immunological characteristics and microbiota composition</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Folia Microbiologica

ISSN

0015-5632

e-ISSN

—

Volume of the periodical

62

Issue of the periodical within the volume

6

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

5

Pages from-to

479-483

UT code for WoS article

000412456500004

EID of the result in the Scopus database

2-s2.0-85016114506