Maternal Allergy Status Has No Impact on Neonatal Immune Responses to Allergen Stimuli

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F19%3A10410364" target="_blank" >RIV/00216208:11110/19:10410364 - isvavai.cz</a>

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=xK.Zg7rP_L" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=xK.Zg7rP_L</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Maternal Allergy Status Has No Impact on Neonatal Immune Responses to Allergen Stimuli

Original language description

Due to the increasing incidence of allergic diseases, there is a strong need to identify a prognostic marker pointing to increased risk of allergy development allowing introduction of early preventive measures. Cord blood seems to be a good source for searching for such marker. The capacity of cord blood cells to respond to common allergens could point to increased predisposition to later allergy development. In our study, cytokines typical of Th1 (IFN-γ), Th2 (IL-5, IL-13) and Treg (IL-10) immune responses were followed at both the level of gene expression and cytokine secretion in cord blood cells of newborns of healthy mothers (children with relatively low risk of allergy development) and allergic mothers (children with relatively high risk of allergy development) stimulated by allergens (pollen from birch and timothy grass, house dust mite, ovalbumin). We have not observed any difference in the response of cord blood cells of neonates of healthy and allergic mothers to allergen in vitro. Both gene expression and secretion of cytokines in response to allergen stimulation were comparable with the unstimulated controls. It seems that early postnatal events will be more decisive for future allergy development than prenatal sensitization of the foetal immune system with allergen in utero in allergic mothers.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30102 - Immunology

Project

<a href="/en/project/NV15-26877A" target="_blank" >NV15-26877A: Effect of early postnatal colonisation of newborns by E. coli on allergy incidence, selected immunological characteristics and microbiota composition</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Folia Biologica

ISSN

0015-5500

e-ISSN

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Volume of the periodical

65

Issue of the periodical within the volume

5-6

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

221-226

UT code for WoS article

000576686100003

EID of the result in the Scopus database

2-s2.0-85086355061