Changes to Fetal Steroidogenesis Caused by Maternal Smoking

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10364719" target="_blank" >RIV/00216208:11110/17:10364719 - isvavai.cz</a>

Alternative codes found

RIV/00023761:_____/17:N0000028 RIV/00064165:_____/17:10364719

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/66/66_S375.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/66/66_S375.pdf</a>

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Changes to Fetal Steroidogenesis Caused by Maternal Smoking

Original language description

Smoking during pregnancy presents health risks for both the mother and her child. In this study we followed changes in the production of steroid hormones in pregnant smokers. We focused on changes in steroidogenesis in the blood of mothers in their 37th week of pregnancy and in mixed cord blood from their newborns. The study included 88 healthy women with physiological pregnancies (17 active smokers and 71 nonsmokers). We separately analyzed hormonal changes associated with smoking according to the sex of newborns. In women with male fetuses, we found higher levels of serum cortisone, dehydroepiandrosterone (DHEA), 7 alpha-OH-DHEA, 17-OH pregnenolone, testosterone, and androstenedione in smokers at the 37th week compared to non-smokers. In women with female fetuses, we found lower serum levels of 7 beta-OH-DHEA and higher androstenedione in smokers at the 37th week. We found significantly higher levels of testosterone in newborn males of smokers and higher levels of 7 alpha-OH-DHEA in female newborns of smokers. Smoking during pregnancy induces changes in the production of steroids in both the mother and her child. These changes are different for different fetal sexes, with more pronounced changes in mothers carrying male newborns as well as in the newborn males themselves.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

—

Volume of the periodical

66

Issue of the periodical within the volume

Suppl. 3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

12

Pages from-to

"S375"-"S386"

UT code for WoS article

000412737900012

EID of the result in the Scopus database

—