Discordance between clinical and pathological TNM classification: influence on results of treatment and prognosis in patients with laryngeal cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10365427" target="_blank" >RIV/00216208:11110/17:10365427 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/17:10365427 RIV/00179906:_____/17:10365427 RIV/00064203:_____/17:10427546

Result on the web

<a href="http://dx.doi.org/10.4149/neo_2017_219" target="_blank" >http://dx.doi.org/10.4149/neo_2017_219</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/neo_2017_219" target="_blank" >10.4149/neo_2017_219</a>

Result language

angličtina

Original language name

Discordance between clinical and pathological TNM classification: influence on results of treatment and prognosis in patients with laryngeal cancer

Original language description

The goals of this retrospective cohort study were to compare the results of clinical and pathological TNM staging in patients with laryngeal squamous cell carcinoma and to determine the impact of the discordance on prognosis and treatment results. A total of 124 patients with laryngeal cancer, primarily indicated for surgical treatment, were enrolled. The concordance or discordance between the clinical and pathological staging was compared with the frequency of cancer relapse and disease-specific survival. Other potential prognostic factors, like age, the stage and location of the primary tumor, the status of neck lymph nodes, histological margins, and an indication for postoperative radiotherapy, were also evaluated. A disparity in at least one component of TNM staging was found in 40 patients (32%). The discordance had significant negative influence on both disease-free survival (DSF) and disease-specific survival (DSS). Other significant negative prognostic factors were the stage of the primary tumor, nodal status and postoperative radiotherapy. Our results indicate that the discordance between clinical and pathological staging affects the results of cancer treatment significantly. Some improvement can be probably achieved with higher preoperative diagnostic method accuracy.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30206 - Otorhinolaryngology

Project

<a href="/en/project/LM2010004" target="_blank" >LM2010004: BBMRI_CZ in the building of the Czech part of a large distributed research infrastructure of pan-European importance: the creation and operation of the network of banks of biological material for biomedical research</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neoplasma

ISSN

0028-2685

e-ISSN

—

Volume of the periodical

64

Issue of the periodical within the volume

2

Country of publishing house

SK - SLOVAKIA

Number of pages

6

Pages from-to

305-310

UT code for WoS article

000402091900019

EID of the result in the Scopus database

2-s2.0-85020440961