The development and origins of vertebrate meninges
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10366841" target="_blank" >RIV/00216208:11110/17:10366841 - isvavai.cz</a>
Result on the web
<a href="https://biocomm.spbu.ru/article/view/10/75" target="_blank" >https://biocomm.spbu.ru/article/view/10/75</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.21638/11701/spbu03.2017.203" target="_blank" >10.21638/11701/spbu03.2017.203</a>
Alternative languages
Result language
angličtina
Original language name
The development and origins of vertebrate meninges
Original language description
Meninges comprise three distinct layers, the dura mater, arachnoid, and pia mater that surround the brain, spinal cord and some parts of the nerves. Tradi- tionally the meninges were believed to serve only as protection for tissues that they encase. However recent work shows they have other important functions related to development and regulation of the nervous system. Given the impor- tance of the meninges, it is surprising that we know very little about their devel- opment. The embryological origin of the meninges has been debated for over a hundred years. Some studies imply that the meninges develop from the neural crest, while others suggest that they come from the somites. Here, we investi- gated the temporal development of meninges in birds and mice and found they form at comparable stages. We investigated the origin of avian spinal meninges using chick/quail cell tracing protocols and found they do not develop from the somites as previously thought. We propose that meningeal epithelial blood vessels may have been mistaken as meninges and led to an erroneous conclu- sion by previous investigators. We present data that show that avian spinal me- ninges originated from the neural crest supported by data demonstrating that they express the neural crest marker HNK1. Finally using the Wnt1-Cre mouse we show that trunk meninges of mammals also originate from neural crest.
Czech name
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Czech description
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Classification
Type
J<sub>ost</sub> - Miscellaneous article in a specialist periodical
CEP classification
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OECD FORD branch
10605 - Developmental biology
Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biological Communications
ISSN
2542-2154
e-ISSN
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Volume of the periodical
62
Issue of the periodical within the volume
2
Country of publishing house
RU - RUSSIAN FEDERATION
Number of pages
9
Pages from-to
73-81
UT code for WoS article
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EID of the result in the Scopus database
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