Meropenem-induced Valproic Acid Elimination: A Case Report of Clinically Relevant Drug Interaction
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10369195" target="_blank" >RIV/00216208:11110/17:10369195 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/17:10369195
Result on the web
<a href="https://pmr.lf1.cuni.cz/media/pdf/pmr_2017118020105.pdf" target="_blank" >https://pmr.lf1.cuni.cz/media/pdf/pmr_2017118020105.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.14712/23362936.2017.11" target="_blank" >10.14712/23362936.2017.11</a>
Alternative languages
Result language
angličtina
Original language name
Meropenem-induced Valproic Acid Elimination: A Case Report of Clinically Relevant Drug Interaction
Original language description
We present two case reports of drug interaction between valproic acid and meropenem. In comparison with expected population-kinetic based serum levels, we observed 90.8 and 93.5% decrease in valproic acid serum levels during concomitant administration with meropenem. If carbapenems need to be administered to valproic acid treated patient, other anticonvulsant addition seems to be the appropriate as most probably the valproic acid dose escalation would not be sufficient to achieve therapeutic serum concentration.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Prague Medical Report
ISSN
1214-6994
e-ISSN
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Volume of the periodical
118
Issue of the periodical within the volume
2-3
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
5
Pages from-to
105-109
UT code for WoS article
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EID of the result in the Scopus database
2-s2.0-85040008750