Dry versus hydrated collagen scaffolds: are dry states representative of hydrated states?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10371399" target="_blank" >RIV/00216208:11110/18:10371399 - isvavai.cz</a>

Alternative codes found

RIV/67985891:_____/18:00497265 RIV/68407700:21220/18:00318334 RIV/00216208:11140/18:10371399 RIV/00064165:_____/18:10371399

Result on the web

<a href="https://link.springer.com/article/10.1007%2Fs10856-017-6024-2" target="_blank" >https://link.springer.com/article/10.1007%2Fs10856-017-6024-2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10856-017-6024-2" target="_blank" >10.1007/s10856-017-6024-2</a>

Result language

angličtina

Original language name

Dry versus hydrated collagen scaffolds: are dry states representative of hydrated states?

Original language description

Collagen composite scaffolds have been used for a number of studies in tissue engineering. The hydration of such highly porous and hydrophilic structures may influence mechanical behaviour and porosity due to swelling. The differences in physical properties following hydration would represent a significant limiting factor for the seeding, growth and differentiation of cells in vitro and the overall applicability of such hydrophilic materials in vivo. Scaffolds based on collagen matrix, poly(DL-lactide) nanofibers, calcium phosphate particles and sodium hyaluronate with 8 different material compositions were characterised in the dry and hydrated states using X-ray microcomputed tomography, compression tests, hydraulic permeability measurement, degradation tests and infrared spectrometry. Hydration, simulating the conditions of cell seeding and cultivation up to 48 h and 576 h, was found to exert a minor effect on the morphological parameters and permeability. Conversely, hydration had a major statistically significant effect on the mechanical behaviour of all the tested scaffolds. The elastic modulus and compressive strength of all the scaffolds decreased by ~95%. The quantitative results provided confirm the importance of analysing scaffolds in the hydrated rather than the dry state since the former more precisely simulates the real environment for which such materials are designed.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30306 - Sport and fitness sciences

Project

<a href="/en/project/NV15-25813A" target="_blank" >NV15-25813A: Development and comprehensive pre-clinical testing of novel composite materials for bone surgery</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Materials Science: Materials in Medicine

ISSN

0957-4530

e-ISSN

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Volume of the periodical

29

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

14

Pages from-to

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UT code for WoS article

000426609600002

EID of the result in the Scopus database

2-s2.0-85041447692