Angiopoietin-like protein 3 and 4 in obesity, type 2 diabetes mellitus, and malnutrition: the effect of weight reduction and realimentation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10376124" target="_blank" >RIV/00216208:11110/18:10376124 - isvavai.cz</a>

Alternative codes found

RIV/00023761:_____/18:N0000004 RIV/00023001:_____/18:00076901 RIV/00064165:_____/18:10376124

Result on the web

<a href="https://doi.org/10.1038/s41387-018-0032-2" target="_blank" >https://doi.org/10.1038/s41387-018-0032-2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41387-018-0032-2" target="_blank" >10.1038/s41387-018-0032-2</a>

Result language

angličtina

Original language name

Angiopoietin-like protein 3 and 4 in obesity, type 2 diabetes mellitus, and malnutrition: the effect of weight reduction and realimentation

Original language description

Background: Angiopoietin-like proteins (ANGPTLs) 3 and 4 are circulating factors that participate in the regulation of lipid and glucose metabolism. Subjects and methods: We measured serum ANGPTL3 and 4 levels in 23 patients with obesity, 40 patients with obesity and type 2 diabetes mellitus (T2DM), 22 patients with anorexia nervosa (AN), 15 subjects undergoing 72-h fasting, and 12 patients with short bowel syndrome (SBS), and their changes after very-low-calorie diet (VLCD), bariatric surgery, partial realimentation, acute fasting, and parenteral nutrition in order to assess their possible role in metabolic regulations. Results: Serum ANGPTL4 levels were higher in obese subjects without/with T2DM (94.50 +- 9.51 and 134.19 +- 7.69 vs. 50.34 +- 4.22 ng/ml, p &lt; 0.001) and lower in subjects with AN relative to healthy control subjects (38.22 +- 4.48 vs. 65.80 +- 7.98 ng/ml, p = 0.002), while serum ANGPTL3 levels demonstrated inverse tendency. Nutritional status had no effect on ANGPTL3 and 4 mRNA expression in adipose tissue. Fasting decreased ANGPTL3 and increased ANGPTL4 levels, while VLCD reduced only ANGPTL3. Bariatric surgery and realimentation of AN or SBS patients had no effect on either ANGPTL. Multiple regression analysis identified BMI as an independent predictor of ANGPTL3; and BMI and HbA1c as independent predictors of ANGPTL4, respectively. Conclusions: Taken together, our data suggest that serum ANGPTL3 and 4 levels are influenced by nutritional status and fasting and could be involved in the metabolic disturbances present in obesity and AN.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

<a href="/en/project/NV15-27863A" target="_blank" >NV15-27863A: The role of gastrointestinal hormones and endocrine dysfunction of the gut in the etiopathogenesis of short bowel syndrome</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nutrition &amp; Diabetes [online]

ISSN

2044-4052

e-ISSN

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Volume of the periodical

8

Issue of the periodical within the volume

April

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

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UT code for WoS article

000431723000004

EID of the result in the Scopus database

2-s2.0-85046120737