An Alternatively Activated Macrophage Marker CD163 in Severely Obese Patients: the Influence of Very Low-Calorie Diet and Bariatric Surgery

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61383082%3A_____%2F17%3A00000377" target="_blank" >RIV/61383082:_____/17:00000377 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/17:10364724 RIV/00023761:_____/17:N0000031 RIV/00023001:_____/17:00076180 RIV/00216208:11110/17:10364724 RIV/00064165:_____/17:10364724

Result on the web

<a href="https://www.ncbi.nlm.nih.gov/pubmed/28406702" target="_blank" >https://www.ncbi.nlm.nih.gov/pubmed/28406702</a>

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

An Alternatively Activated Macrophage Marker CD163 in Severely Obese Patients: the Influence of Very Low-Calorie Diet and Bariatric Surgery

Original language description

CD163 is a marker of macrophages with anti-inflammatory properties and its soluble form (sCD163) is considered a prognostic predictor of several diseases including type 2 diabetes mellitus (T2DM). We explored sCD163 levels at baseline and after very low-calorie diet (VLCD) or bariatric surgery in 32 patients with obesity (20 undergoing VLCD and 12 bariatric surgery), 32 obese patients with T2DM (22 undergoing VLCD and 10 bariatric surgery), and 19 control subjects. We also assessed the changes of CD163 positive cells of monocyte-macrophage lineage in peripheral blood and subcutaneous adipose tissue (SAT) in subset of patients. Plasma sCD163 levels were increased in obese and T2DM subjects relative to control subjects (467.2 +/- 40.2 and 513.8 +/- 37.0 vs. 334.4 +/- 24.8 ng/ml, p=0.001) and decreased after both interventions. Obesity decreased percentage of CD163+ CD14+ monocytes in peripheral blood compared to controls (78.9 +/- 1.48 vs. 86.2 +/- 1.31 %, p=0.003) and bariatric surgery decreased CD163+ CD14+ HLA-DR+ macrophages in SAT (19.4 +/- 2.32 vs. 11.3 +/- 0.90 %, p=0.004). Our data suggest that increased basal sCD163 levels are related to obesity and its metabolic complications. On the contrary, sCD163 or CD163 positive cell changes do not precisely reflect metabolic improvements after weight loss.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30212 - Surgery

Project

<a href="/en/project/NV15-26854A" target="_blank" >NV15-26854A: The role of epicardial adipose tissue in heart disease: novel mechanisms of action and its therapeutic modulation</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

—

Volume of the periodical

66

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

12

Pages from-to

641-652

UT code for WoS article

000412736000010

EID of the result in the Scopus database

—