Expression of soluble sCD163 in serum of psoriatic patients is modulated by Goeckerman therapy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F13%3A10139484" target="_blank" >RIV/00179906:_____/13:10139484 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/13:10139484

Result on the web

<a href="http://dx.doi.org/10.1016/j.aller.2012.02.006" target="_blank" >http://dx.doi.org/10.1016/j.aller.2012.02.006</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.aller.2012.02.006" target="_blank" >10.1016/j.aller.2012.02.006</a>

Result language

angličtina

Original language name

Expression of soluble sCD163 in serum of psoriatic patients is modulated by Goeckerman therapy

Original language description

Background: CD163 is the monocyte/macrophage receptor for haptoglobin-haemoglobin complexes. The aim of this study was to assess the kinetics in the expression of CD163 on monocytes and the concentration of soluble sCD163 in serum of psoriatic patients in order to examine the effect of Goeckerman therapy. Methods: sCD163 was measured in 71 patients before and after therapy, and in 57 healthy donors. A subgroup of 40 patients and 25 controls was used to assess the expression of membrane CD163. sCD163 wasevaluated by ELISA. Flow cytometry method was used to determine the expression of membrane CD163 on monocytes, expressed as mean fluorescence index (MFI). Results: Before therapy, the serum level of sCD163 was significantly higher in our patients than in controls (P=0.0154). However, we observed a profound decrease in sCD163 in our patients after therapy (P=0.0037). Similar to sCD163, pre-treatment expression of CD163 on monocytes was significantly more enhanced in patients than that in

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FN - Epidemiology, infection diseases and clinical immunology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Allergologia et Immunopathologia

ISSN

0301-0546

e-ISSN

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Volume of the periodical

41

Issue of the periodical within the volume

3

Country of publishing house

ES - SPAIN

Number of pages

5

Pages from-to

158-162

UT code for WoS article

000320343200004

EID of the result in the Scopus database

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