Urine sCD163: a window onto glomerular inflammation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10337406" target="_blank" >RIV/00064165:_____/16:10337406 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/16:10337406
Result on the web
<a href="http://dx.doi.org/10.1093/ndt/gfw257" target="_blank" >http://dx.doi.org/10.1093/ndt/gfw257</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/ndt/gfw257" target="_blank" >10.1093/ndt/gfw257</a>
Alternative languages
Result language
angličtina
Original language name
Urine sCD163: a window onto glomerular inflammation
Original language description
Several antibodies to an unknown monocyte/macrophage-specific antigen were described in the 1980s and 1990s, leading to the CD163 designation at the 6th Leukocyte Typing Workshop in 1996. The principal function of this membrane-bound protein as a monocyte/macrophage-specific scavenger receptor for haemoglobin-haptoglobin complexes was described in 2001, and soon after it was realized that relatively high concentrations of a soluble form of the receptor are present in the circulation (soluble CD163, sCD163). The soluble form probably functions as part of the innate immune defence by reversibly binding bacteria and free haemoglobin in the circulation for further processing by the immune system. However, due to the high and specific expression on macrophages, sCD163 has gained much attention as a potential biomarker reflecting macrophage activation in inflammatory conditions.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nephrology, Dialysis, Transplantation
ISSN
0931-0509
e-ISSN
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Volume of the periodical
31
Issue of the periodical within the volume
12
Country of publishing house
GB - UNITED KINGDOM
Number of pages
3
Pages from-to
1970-1972
UT code for WoS article
000393059700002
EID of the result in the Scopus database
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