Interactions Among Polymorphisms of Susceptibility Loci for Alzheimer's Disease or Depressive Disorder
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10376725" target="_blank" >RIV/00216208:11110/18:10376725 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/18:10376725
Result on the web
<a href="https://doi.org/10.12659/MSM.907202" target="_blank" >https://doi.org/10.12659/MSM.907202</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.12659/MSM.907202" target="_blank" >10.12659/MSM.907202</a>
Alternative languages
Result language
angličtina
Original language name
Interactions Among Polymorphisms of Susceptibility Loci for Alzheimer's Disease or Depressive Disorder
Original language description
Background: Several genetic susceptibility loci for major depressive disorder (MDD) or Alzheimer's disease (AD) have been described. Interactions among polymorphisms are thought to explain the differences between low- and highrisk groups. We tested for the contribution of interactions between multiple functional polymorphisms in the risk of MDD or AD. Material/Methods: A genetic association case-control study was performed in 68 MDD cases, 84 AD cases (35 of them with comorbid depression), and 90 controls. The contribution of 7 polymorphisms from 5 genes (APOE, HSPA1A, SLC6A4, HTR2A, and BDNF) related to risk of MDD or AD development was analyzed. Results: Significant associations were found between MDD and interactions among polymorphisms in HSPA1A, SLC6A4, and BDNF or HSPA1A, BDNF, and APOE genes. For polymorphisms in the APOE gene in AD, significant differences were confirmed on the distributions of alleles and genotype rates compared to the control or MDD. Increased probability of comorbid depression was found in patients with AD who do not carry the epsilon 4 allele of APOE. Conclusions: Assessment of the interactions among polymorphisms of susceptibility loci in both MDD and AD confirmed a synergistic effect of genetic factors influencing inflammatory, serotonergic, and neurotrophic pathways at these heterogenous complex diseases. The effect of interactions was greater in MDD than in AD. A presence of the e4 allele was confirmed as a genetic susceptibility factor in AD. Our findings indicate a role of APOE genotype in onset of comorbid depression in a subgroup of patients with AD who are not carriers of the APOE epsilon 4 allele.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30215 - Psychiatry
Result continuities
Project
<a href="/en/project/GA17-05292S" target="_blank" >GA17-05292S: Novel blood-based biomarkers for early diagnosis, prognosis and progress of Alzheimer's disease</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Medical Science Monitor [online]
ISSN
1643-3750
e-ISSN
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Volume of the periodical
24
Issue of the periodical within the volume
April
Country of publishing house
US - UNITED STATES
Number of pages
21
Pages from-to
2599-2619
UT code for WoS article
000431079300001
EID of the result in the Scopus database
2-s2.0-85046645012