Interplay between the APOE Genotype and Possible Plasma Biomarkers in Alzheimer's Disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10378642" target="_blank" >RIV/00216208:11110/18:10378642 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/18:10378642

Result on the web

<a href="https://doi.org/10.2174/1567205015666180601090533" target="_blank" >https://doi.org/10.2174/1567205015666180601090533</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/1567205015666180601090533" target="_blank" >10.2174/1567205015666180601090533</a>

Result language

angličtina

Original language name

Interplay between the APOE Genotype and Possible Plasma Biomarkers in Alzheimer's Disease

Original language description

Background: Alzheimer&apos;s disease (AD) is a progressive neurodegenerative disorder with a complex pathogenesis and a common occurrence of comorbid diseases such as depression. It is accepted that the presence of the epsilon 4 allele of the gene that encodes apolipoprotein E (APOE) is the strongest genetic risk factor for the development of sporadic AD. Melatonin, cortisol, homocysteine, and prolactin are presumed to be risk factors or biomarkers for stress- and age-related disorders. Objective: The interplay between the APOE genotype and plasma biomarkers was examined in patients with AD presenting with or without depression to contribute to understanding the interdependence of various molecular mechanisms in the pathophysiology of AD. Method: The APOE genotype and morning plasma melatonin, cortisol, homocysteine, and prolactin concentrations were measured in 85 patients with AD and 44 elderly controls. Results: A significant association between AD and the allele (epsilon 4) or genotype (epsilon 3/epsilon 4 or epsilon 4/epsilon 4) frequencies of APOE was confirmed. Plasma homocysteine and cortisol levels were significantly increased in patients with AD compared to those in controls, independent of the presence of comorbid depressive symptoms or the severity of dementia. Significantly lower plasma melatonin concentration was found in patients with AD but not in controls, who were noncarriers of the APOE epsilon 4 allele, regardless of the presence of depression or the severity of dementia in AD. Conclusion: Our findings indicate the existence of a little-known specific APOE-mediated mechanism that increases the plasma melatonin level in a subgroup of patients with AD who are carriers of the APOE epsilon 4 allele.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

<a href="/en/project/GA17-05292S" target="_blank" >GA17-05292S: Novel blood-based biomarkers for early diagnosis, prognosis and progress of Alzheimer's disease</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Current Alzheimer Research

ISSN

1567-2050

e-ISSN

—

Volume of the periodical

15

Issue of the periodical within the volume

10

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

13

Pages from-to

938-950

UT code for WoS article

000442171000005

EID of the result in the Scopus database

2-s2.0-85051840048