Specialized impulse conduction pathway in the alligator heart

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10376729" target="_blank" >RIV/00216208:11110/18:10376729 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/18:00490367

Result on the web

<a href="https://doi.org/10.7554/eLife.32120" target="_blank" >https://doi.org/10.7554/eLife.32120</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.7554/eLife.32120" target="_blank" >10.7554/eLife.32120</a>

Result language

angličtina

Original language name

Specialized impulse conduction pathway in the alligator heart

Original language description

Mammals and birds have a specialized cardiac atrioventricular conduction system enabling rapid activation of both ventricles. This system may have evolved together with high heart rates to support their endothermic state (warm-bloodedness) and is seemingly lacking in ectothermic vertebrates from which first mammals then birds independently evolved. Here, we studied the conduction system in crocodiles (Alligator mississippiensis), the only ectothermic vertebrates with a full ventricular septum. We identified homologues of mammalian conduction system markers (Tbx3-Tbx5, Scn5a, Gja5, Nppa-Nppb) and show the presence of a functional atrioventricular bundle. The ventricular Purkinje network, however, was absent and slow ventricular conduction relied on trabecular myocardium, as it does in other ectothermic vertebrates. We propose the evolution of the atrioventricular bundle followed full ventricular septum formation prior to the development of high heart rates and endothermy. In contrast, the evolution of the ventricular Purkinje network is strongly associated with high heart rates and endothermy.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30106 - Anatomy and morphology (plant science to be 1.6)

Project

<a href="/en/project/GA16-02972S" target="_blank" >GA16-02972S: Elucidating cardiac conduction system formation with phylogenetic approaches</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

eLife

ISSN

2050-084X

e-ISSN

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Volume of the periodical

7

Issue of the periodical within the volume

March

Country of publishing house

GB - UNITED KINGDOM

Number of pages

20

Pages from-to

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UT code for WoS article

000431623100001

EID of the result in the Scopus database

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