The role of obesity and adipose tissue dysfunction in gestational diabetes mellitus
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10376819" target="_blank" >RIV/00216208:11110/18:10376819 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/18:43916892 RIV/00023761:_____/18:N0000024 RIV/00064173:_____/18:N0000033 RIV/00023001:_____/18:00077069 RIV/00064165:_____/18:10376819
Result on the web
<a href="https://doi.org/10.1530/JOE-18-0032" target="_blank" >https://doi.org/10.1530/JOE-18-0032</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1530/JOE-18-0032" target="_blank" >10.1530/JOE-18-0032</a>
Alternative languages
Result language
angličtina
Original language name
The role of obesity and adipose tissue dysfunction in gestational diabetes mellitus
Original language description
Gestational diabetes mellitus is defined as diabetes diagnosed in the second or third trimester of pregnancy in patients with no history of diabetes prior to gestation. It is the most common complication of pregnancy. The underlying pathophysiology shares some common features with type 2 diabetes mellitus (T2DM) combining relatively insufficient insulin secretion with increased peripheral insulin resistance. While a certain degree of insulin resistance is the physiological characteristics of the second half of pregnancy, it is significantly more pronounced in patients with gestational diabetes. Adipose tissue dysfunction and subclinical inflammation in obesity are well-described causes of increased insulin resistance in non-pregnant subjects and are often observed in individuals with T2DM. Emerging evidence of altered adipokine expression and local inflammation in adipose tissue in patients with gestational diabetes suggests an important involvement of adipose tissue in its etiopathogenesis. This review aims to summarize current knowledge of adipose tissue dysfunction and its role in the development of gestational diabetes. We specifically focus on the significance of alterations of adipokines and immunocompetent cells number and phenotype in fat. Detailed understanding of the role of adipose tissue in gestational diabetes may provide new insights into its pathophysiology and open new possibilities of its prevention and treatment.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)
Result continuities
Project
<a href="/en/project/NV15-27630A" target="_blank" >NV15-27630A: Endocrine function of adipose tissue in the etiopathogenesis of the gestational diabetes.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Endocrinology
ISSN
0022-0795
e-ISSN
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Volume of the periodical
238
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
15
Pages from-to
"R63"-"R77"
UT code for WoS article
000438707700001
EID of the result in the Scopus database
2-s2.0-85049487936