The possible role of endocrine dysfunction of adipose tissue in gestational diabetes mellitus

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F20%3A10416785" target="_blank" >RIV/00216208:11110/20:10416785 - isvavai.cz</a>

Alternative codes found

RIV/00023001:_____/20:00080279 RIV/00064165:_____/20:10416785

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=bf2WAFfkM~" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=bf2WAFfkM~</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.23736/S0391-1977.20.03192-2" target="_blank" >10.23736/S0391-1977.20.03192-2</a>

Result language

angličtina

Original language name

The possible role of endocrine dysfunction of adipose tissue in gestational diabetes mellitus

Original language description

Gestational diabetes mellitus (GDM) is diabetes that is first diagnosed in the second or third trimester of pregnancy in patients who did not have a history of diabetes before pregnancy. Consequences of GDM include increased risk of macrosomia and birth complications in the infant and an increased risk of maternal type 2 diabetes mellitus (T2DM) after pregnancy. There is also a longer-term risk of obesity, T2DM, and cardiovascular diseases in the child. GDM is the result of impaired glucose tolerance due to pancreatic beta-cell dysfunction on a background of insulin resistance that physiologically increases during pregnancy. The strongest clinical predictors of GDM are overweight and obesity. The fact that women with GDM are more likely to be overweight or obese suggests that adipose tissue dysfunction may be involved in the pathogenesis of GDM, similarly to T2DM. Adipose tissue is not only involved in energy storage but also functions as an active endocrine organ secreting adipokines (specific hormones and cytokines) with the ability to alter insulin sensitivity. Recent evidence points to a crucial role of numerous adipokines produced by fat in the development of GDM. The following text summarizes the current knowledge about a possible role of selected adipokines in the development of GDM.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

<a href="/en/project/NU20-01-00067" target="_blank" >NU20-01-00067: The effect of diabetes compensation on placental function and fetal circulation in pregnant women with type 1 diabetes mellitus.</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Minerva Endocrinologica

ISSN

0391-1977

e-ISSN

—

Volume of the periodical

45

Issue of the periodical within the volume

3

Country of publishing house

IT - ITALY

Number of pages

15

Pages from-to

228-242

UT code for WoS article

000577261900006

EID of the result in the Scopus database

2-s2.0-85092493526