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Serum calprotectin may reflect inflammatory activity in patients with active rheumatoid arthritis despite normal to low C-reactive protein

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10377143" target="_blank" >RIV/00216208:11110/18:10377143 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11510/18:10377143 RIV/00023728:_____/18:N0000075

  • Result on the web

    <a href="https://doi.org/10.1007/s10067-018-4091-5" target="_blank" >https://doi.org/10.1007/s10067-018-4091-5</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s10067-018-4091-5" target="_blank" >10.1007/s10067-018-4091-5</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Serum calprotectin may reflect inflammatory activity in patients with active rheumatoid arthritis despite normal to low C-reactive protein

  • Original language description

    Approximately half of patients with rheumatoid arthritis (RA) have normal C-reactive protein (CRP) levels. Calprotectin is a promising and likely more specific biomarker of disease activity than conventionally used acute phase reactants. We aimed to analyse the levels of serum calprotectin in RA patients with clinically active disease and with normal/low CRP. A total of 160 RA patients underwent clinical examination (DAS28-ESR and CDAI). The levels of calprotectin were analysed in patients with moderate to high disease activity with normal/low CRP levels and in 32 healthy subjects. The discriminatory capacity of calprotectin to identify clinically active patients in spite of normal/low CRP was assessed using ROC curves. Out of all RA patients, 74/160 (46.3%) were in remission or had low disease activity according to DAS28 and had normal/low CRP levels. However, 51/160 (32%) had normal/low CRP levels despite having moderate to high disease activity. In these patients, calprotectin levels were significantly higher than those in patients who had normal/low CRP and were in remission or showed low disease activity (2.7 +/- 1.5 vs. 2.1 +/- 1.2 mu g/mL, p = 0.043), which differed from those in healthy subjects (2.7 +/- 1.5 vs. 1.9 +/- 1.2 mu g/mL, p = 0.011). The discriminatory capacity for calprotectin to distinguish clinically active vs. inactive disease despite normal/low CRP using AUC of the DAS28 was 0.607 (95% CI 0.503 to 0.711, p = 0.043). The present study demonstrates that calprotectin may reflect inflammatory activity in RA patients where CRP fails to do so.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30226 - Rheumatology

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Clinical Rheumatology

  • ISSN

    0770-3198

  • e-ISSN

  • Volume of the periodical

    37

  • Issue of the periodical within the volume

    8

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    8

  • Pages from-to

    2055-2062

  • UT code for WoS article

    000438277700005

  • EID of the result in the Scopus database

    2-s2.0-85045274374