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Excellent Glycemic Control Maintained by Open-Source Hybrid Closed-Loop AndroidAPS During and After Sustained Physical Activity

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10381331" target="_blank" >RIV/00216208:11110/18:10381331 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11130/18:10381331 RIV/00064203:_____/18:10381331

  • Result on the web

    <a href="https://doi.org/10.1089/dia.2018.0214" target="_blank" >https://doi.org/10.1089/dia.2018.0214</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1089/dia.2018.0214" target="_blank" >10.1089/dia.2018.0214</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Excellent Glycemic Control Maintained by Open-Source Hybrid Closed-Loop AndroidAPS During and After Sustained Physical Activity

  • Original language description

    Objective: Officially licensed hybrid closed-loop systems are not currently available worldwide; therefore, open-source systems have become increasingly popular. Our aim was to assess the safety, feasibility, and efficacy of an open-source hybrid closed-loop system (AndroidAPS) versus SmartGuard((R)) technology for day-and-night glucose control in children under extreme sports conditions. Research Design and Methods: Twenty-two children (16 girls, 6-15 years of age, median HbA1c 569mmol/mol) were enrolled in this pivotal winter sports camp study. The participants were divided into two groups using either the AndroidAPS or SmartGuard technology. Physical exertion was represented by all-day alpine skiing. The primary endpoints were mean glucose level, time below the threshold of 3.9mmol/L, and time within the target range of 3.9 to 10mmol/L. Results: The children using the AndroidAPS had significantly lower mean glycemia levels (7.2 +/- 2.7 vs. 7.7 +/- 2.8mmol/L; 129.6 +/- 49 vs. 138.6 +/- 50mg/dL, P&lt;0.042) than the children using the SmartGuard. The proportion of time below the target (median 5.0%+/- 2.5% vs. 3.0%+/- 2.3%, P=0.6) and in the target zone (63%+/- 9.5% vs. 63%+/- 18%, P=0.5) did not significantly differ. The AndroidAPS group experienced more frequent malfunctions of the cannula set (median 0.8 +/- 0.4 vs. 0.2 +/- 0.4, P=0.02), which could have affected the results. No significant difference was found in the amount of carbohydrates consumed for the prevention and treatment of hypoglycemia [median 40 +/- 23 vs. 25 +/- 29g/(patient &lt;bold&gt;&lt;/bold&gt;3 days)]. No episodes of severe hypoglycemia or other serious adverse events were noted. Conclusions: This pilot study showed that the AndroidAPS system was a safe and feasible alternative to the SmartGuard Technology.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30202 - Endocrinology and metabolism (including diabetes, hormones)

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Diabetes Technology &amp; Therapeutics

  • ISSN

    1520-9156

  • e-ISSN

  • Volume of the periodical

    neuveden

  • Issue of the periodical within the volume

    October

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    7

  • Pages from-to

  • UT code for WoS article

    000446458100001

  • EID of the result in the Scopus database

    2-s2.0-85055854919