31P-MR spectroscopy in patients with mild and serious lower limb ischemia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10381820" target="_blank" >RIV/00216208:11110/18:10381820 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.23736/S0392-9590.18.03943-3" target="_blank" >https://doi.org/10.23736/S0392-9590.18.03943-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.23736/S0392-9590.18.03943-3" target="_blank" >10.23736/S0392-9590.18.03943-3</a>

Result language

angličtina

Original language name

31P-MR spectroscopy in patients with mild and serious lower limb ischemia

Original language description

BACKGROUND: P-31-MR spectroscopy is a technique for undertaking a comprehensive evaluation of muscle metabolism. The goal of this study was to compare patients with mild and severe lower limb ischemia measured by P-31-MR spectroscopy at rest and during exercise. METHODS: Sixteen non-diabetic mild peripheral arterial occlusive disease (PAOD) patients, 23 diabetic PAOD patients with severe ischemia and 19 healthy controls were examined by rest and dynamic P-31-MR spectroscopy with a P-31-MR system equipped with an 3T MR-compatible home-made pedal ergometer. Signal intensity ratios of phosphorous metabolites to the sum of all P-31 intensities (P-tot) and pH were obtained at rest. The PCr drop (Delta PCr), time recovery constant of PCr (tau PCr), pH at the end of the exercise (PHend), and mitochondrial capacity (Q(max)) were calculated from dynamic MR spectra. RESULTS: Diabetic PAOD patients with severe ischemia differed from controls in both rest (PCr/Pi, beta ATP/P-tot pH) and dynamic (Q(max), pH(end), tau PCr) parameters. PAOD patients with mild ischemia differed from controls only in Q(max) and PHend. Rest parameters of the non-diabefic PAOD patients did not differ from control values excluding rest pH which was higher in both patient groups. CONCLUSIONS: A combination of rest and dynamic P-31-MR spectroscopy can distinguish among all three groups of subjects. On the other hand, examination at rest is sufficient for differentiation between patient groups and verification of severe ischemia.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30224 - Radiology, nuclear medicine and medical imaging

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Angiology

ISSN

0392-9590

e-ISSN

—

Volume of the periodical

37

Issue of the periodical within the volume

4

Country of publishing house

IT - ITALY

Number of pages

7

Pages from-to

293-299

UT code for WoS article

000445302300006

EID of the result in the Scopus database

2-s2.0-85049397916