Neuroinflammation markers and methyl alcohol induced toxic brain damage
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10383018" target="_blank" >RIV/00216208:11110/18:10383018 - isvavai.cz</a>
Alternative codes found
RIV/61388955:_____/18:00492513 RIV/00023001:_____/18:00077375 RIV/75010330:_____/18:00012309 RIV/00064165:_____/18:10383018
Result on the web
<a href="https://doi.org/10.1016/j.toxlet.2018.05.001" target="_blank" >https://doi.org/10.1016/j.toxlet.2018.05.001</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.toxlet.2018.05.001" target="_blank" >10.1016/j.toxlet.2018.05.001</a>
Alternative languages
Result language
angličtina
Original language name
Neuroinflammation markers and methyl alcohol induced toxic brain damage
Original language description
Methyl alcohol intoxication is a global problem with high mortality and long-term visual sequelae and severe brain damage in survivors. The role of neuroinflammation in the mechanisms of methyl alcohol-induced toxic brain damage has not been well studied. We measured the acute concentrations and dynamics of lipoxins LxA4 and LxB4 and the interleukins IL-4, IL-5, IL-9, IL-10, and IL-13 in the serum of patients treated with methyl alcohol poisoning and the follow-up concentrations in survivors two years after discharge from the hospital. A series of acute measurements was performed in 28 hospitalized patients (mean age 54.2 +/- 5.2 years, mean observation time 88 +/- 20 h) and the follow-up measurements were performed in 36 subjects who survived poisoning (including 12/28 survivors from the acute group). Visual evoked potentials (VEP) and magnetic resonance imaging of the brain (MRI) were performed to detect long-term visual and brain sequelae of intoxication. The acute concentrations of inflammatory mediators were higher than the follow-up concentrations: LxA4, 62.0 +/- 6.0 vs. 30.0 +/- 5.0 pg/mL; LxB4, 64.0 +/- 7.0 vs. 34.0 +/- 4.0 pg/mL; IL-4, 29.0 +/- 4.0 vs. 15.0 +/- 1.0 pg/mL; IL-5, 30.0 +/- 4.0 vs. 13.0 +/- 1.0 pg/mL; IL-9, 30.0 +/- 4.0 vs. 13.0 +/- 1.0 pg/mL; IL-10, 38.0 +/- 5.0 vs. 16.0 +/- 1.0 pg/mL; IL-13, 35.0 +/- 4.0 vs. 14.0 +/- 1.0 pg/mL (all p < 0.001). The patients with higher follow-up IL-5 concentration had prolonged latency P1 (r=0.413; p=0.033) and lower amplitude N1P1 (r=-0.498; p=0.010) of VEP. The higher follow-up IL-10 concentration was associated with MRI signs of brain necrotic damage (r=0.533; p=0.001) and brain hemorrhage (r=0.396; p=0.020). Our findings suggest that neuroinflammation plays an important role in the mechanisms of toxic brain damage in acute methyl alcohol intoxication.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30108 - Toxicology
Result continuities
Project
<a href="/en/project/NV16-27075A" target="_blank" >NV16-27075A: NEURODEGENERATIVE PROCESSES IN PATIENTS EXPOSED TO METHANOL: PROSPECTIVE STUDY AFTER CZECH MASS METHANOL POISONING OUTBREAK IN 2012</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Toxicology Letters
ISSN
0378-4274
e-ISSN
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Volume of the periodical
298
Issue of the periodical within the volume
December
Country of publishing house
IE - IRELAND
Number of pages
10
Pages from-to
60-69
UT code for WoS article
000450122200009
EID of the result in the Scopus database
2-s2.0-85046815620