Reactive carbonyl compounds, carbonyl stress, and neuroinflammation in methyl alcohol intoxication

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F19%3A00537139" target="_blank" >RIV/61388955:_____/19:00537139 - isvavai.cz</a>

Alternative codes found

RIV/60460709:41210/19:80942 RIV/00216208:11110/19:10400438 RIV/61384399:31140/19:00053889 RIV/75010330:_____/19:00012888 RIV/00064165:_____/19:10400438

Result on the web

<a href="http://hdl.handle.net/11104/0314888" target="_blank" >http://hdl.handle.net/11104/0314888</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00706-019-02429-z" target="_blank" >10.1007/s00706-019-02429-z</a>

Result language

angličtina

Original language name

Reactive carbonyl compounds, carbonyl stress, and neuroinflammation in methyl alcohol intoxication

Original language description

Methyl alcohol intoxications are characterized by high lethality and high prevalence of serious visual and brain damage in survivors. The mechanisms of toxic brain damage are complex and the role of carbonyl stress has not been studied yet. We measured the acute and follow-up concentrations of reactive carbonyl compounds in patients with acute methyl alcohol intoxication. Blood samples were collected from 28 subjects hospitalized with confirmed methyl alcohol intoxication and from 36 subjects who survived poisoning 2 years after discharge. Serum concentrations of C6-12 reactive aldehydes were measured by liquid chromatography-electrospray ionization-tandem mass spectrometry. The acute concentrations of all measured reactive aldehydes were higher than the follow-up concentrations: 36.4 +/- 4.8 vs. 21.6 +/- 5.2 ng cm(-3) for C-6, 38.9 +/- 5 vs. 17.0 +/- 2.0 ng cm(-3) for C-7, 18.8 +/- 3.9 vs. 4 +/- 0 cm(-3) for C-8, 36.5 +/- 3.9 vs. 19.0 +/- 3.0 ng cm(-3) for C-9, 6.1 +/- 0.4 vs. 4.0 +/- 0.5 ng cm(-3) for C-10, 13.6 +/- 3.0 vs. 3.7 +/- 0.6 ng cm(-3) for C-11, and 7.8 +/- 0.4 vs. 4.7 +/- 0.4 ng cm(-3) for C-12 (all p < 0.001). The patients who survived the intoxication had higher concentration of reactive carbonyl compounds than those who died: 38.6 +/- 5.9 vs. 28.3 +/- 1.7 ng cm(-3) for C-6 (p = 0.002), 20.7 +/- 4.7 vs. 11.8 +/- 1.2 ng cm(-3) for C-8 (p = 0.001), 37.7 +/- 4.8 vs. 31.8 +/- 3.8 ng cm(-3) for C-9 (p = 0.042), and 7.9 +/- 0.6 vs. 7.3 +/- 0.5 ng cm(-3) for C-12 (p = 0.022). A significant association was present between severity of metabolic acidosis, anion gap, and the acute concentration of measured biomarkers: r = 0.39, p = 0.046 for C-6, r = 0.42, p = 0.035 for C-7, r = 0.48, p = 0.012 for C-8, r = 0.39, p = 0.046 for C-9, and r = 0.47, p = 0.015 for C-11. The acute concentration of C-6-C-12 reactive aldehydes positively correlated with the acute serum concentration of leukotrienes (all p < 0.05). Acute elevation of serum concentration of reactive carbonyl compounds suggests that carbonyl stress is involved in the mechanisms of leukotriene-mediated neuroinflammatory response to methyl alcohol-induced toxic brain damage.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10403 - Physical chemistry

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Monatshefte fur Chemie

ISSN

0026-9247

e-ISSN

—

Volume of the periodical

150

Issue of the periodical within the volume

9

Country of publishing house

AT - AUSTRIA

Number of pages

8

Pages from-to

1723-1730

UT code for WoS article

000482907600024

EID of the result in the Scopus database

2-s2.0-85068894277