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Optical Mapping Can Reveal Two-Dimensional Morphology of Atrioventricular Insulation in the Foetal Avian Heart

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10386916" target="_blank" >RIV/00216208:11110/18:10386916 - isvavai.cz</a>

  • Result on the web

    <a href="http://www.cinc.org/archives/2018/pdf/CinC2018-055.pdf" target="_blank" >http://www.cinc.org/archives/2018/pdf/CinC2018-055.pdf</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.22489/CinC.2018.055" target="_blank" >10.22489/CinC.2018.055</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Optical Mapping Can Reveal Two-Dimensional Morphology of Atrioventricular Insulation in the Foetal Avian Heart

  • Original language description

    Syndromes of ventricular pre-excitation or atrioventricular (AV) re-entry are believed to results from inappropriate formation of the AV junction (AVJ) during prenatal development. However, technical limitations pose challenge to study foetal heart electrophysiology and are hampering understanding formation of accessory pathways (APs) bypassing AVJ. Here, we present a novel approach of retrograde perfusion for optical mapping of chicken foetal heart. Together with embryonic heart mapping, we were able to investigate AVJ electrical remodelling during the entire prenatal period. AV electrical insulation was observed concomitant to functional deployment of the conduction system at the time of ventricular septation. However, persistence of ectopic AV electrical continuity was still detected in postseptation foetal hearts. APs registered in 40% of prenatal day 13 (localised in the central anterior or left posterior side) were progressively resolved and none were detected on prenatal day 18. The optical mapping approach thus proved its ability to track AVJ electrical remodelling during whole prenatal chicken development and spatiotemporally localise electrically active APs.

  • Czech name

  • Czech description

Classification

  • Type

    D - Article in proceedings

  • CEP classification

  • OECD FORD branch

    30201 - Cardiac and Cardiovascular systems

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    Computing in Cardiology

  • ISBN

    978-1-72810-958-9

  • ISSN

    2325-887X

  • e-ISSN

  • Number of pages

    4

  • Pages from-to

  • Publisher name

    IEEE

  • Place of publication

    USA

  • Event location

    Maastricht, The Netherlands

  • Event date

    Sep 23, 2018

  • Type of event by nationality

    WRD - Celosvětová akce

  • UT code for WoS article

    000482598700281