Optical Mapping Can Reveal Two-Dimensional Morphology of Atrioventricular Insulation in the Foetal Avian Heart
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10386916" target="_blank" >RIV/00216208:11110/18:10386916 - isvavai.cz</a>
Result on the web
<a href="http://www.cinc.org/archives/2018/pdf/CinC2018-055.pdf" target="_blank" >http://www.cinc.org/archives/2018/pdf/CinC2018-055.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.22489/CinC.2018.055" target="_blank" >10.22489/CinC.2018.055</a>
Alternative languages
Result language
angličtina
Original language name
Optical Mapping Can Reveal Two-Dimensional Morphology of Atrioventricular Insulation in the Foetal Avian Heart
Original language description
Syndromes of ventricular pre-excitation or atrioventricular (AV) re-entry are believed to results from inappropriate formation of the AV junction (AVJ) during prenatal development. However, technical limitations pose challenge to study foetal heart electrophysiology and are hampering understanding formation of accessory pathways (APs) bypassing AVJ. Here, we present a novel approach of retrograde perfusion for optical mapping of chicken foetal heart. Together with embryonic heart mapping, we were able to investigate AVJ electrical remodelling during the entire prenatal period. AV electrical insulation was observed concomitant to functional deployment of the conduction system at the time of ventricular septation. However, persistence of ectopic AV electrical continuity was still detected in postseptation foetal hearts. APs registered in 40% of prenatal day 13 (localised in the central anterior or left posterior side) were progressively resolved and none were detected on prenatal day 18. The optical mapping approach thus proved its ability to track AVJ electrical remodelling during whole prenatal chicken development and spatiotemporally localise electrically active APs.
Czech name
—
Czech description
—
Classification
Type
D - Article in proceedings
CEP classification
—
OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Computing in Cardiology
ISBN
978-1-72810-958-9
ISSN
2325-887X
e-ISSN
—
Number of pages
4
Pages from-to
—
Publisher name
IEEE
Place of publication
USA
Event location
Maastricht, The Netherlands
Event date
Sep 23, 2018
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000482598700281