Optical Mapping Can Reveal Two-Dimensional Morphology of Atrioventricular Insulation in the Foetal Avian Heart

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F18%3A00501676" target="_blank" >RIV/67985823:_____/18:00501676 - isvavai.cz</a>

Alternative codes found

RIV/00216305:26220/18:PU129627

Result on the web

<a href="http://www.cinc.org/cinc-papers-on-line/" target="_blank" >http://www.cinc.org/cinc-papers-on-line/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.22489/CinC.2018.055" target="_blank" >10.22489/CinC.2018.055</a>

Result language

angličtina

Original language name

Optical Mapping Can Reveal Two-Dimensional Morphology of Atrioventricular Insulation in the Foetal Avian Heart

Original language description

Syndromes of ventricular pre-excitation or atrio-ventricular (AV) re-entry are believed to results from inappropriate formation of the AV junction (AVJ) during prenatal development. However, technical limitations pose challenge to study foetal heart electrophysiology and are hampering understanding formation of accessory pathways (APs) bypassing AVJ. Here, we present a novel approach of retrograde perfusion for optical mapping of chicken foetal heart. Together with embryonic heart mapping, we were able to investigate AVJ electrical remodelling during the entire prenatal period. AV electrical insulation was observed concomitant to functional deployment of the conduction system at the time of ventricular septation. However, persistence of ectopic AV electrical continuity was still detected in post-septation foetal hearts. APs registered in 40% of prenatal day 13 (localised in the central anterior or left posterior side) were progressively resolved and none were detected on prenatal day 18. The optical mapping approach thus proved its ability to track AVJ electrical remodelling during whole prenatal chicken development and spatiotemporally localise electrically active APs.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

—

OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Computing in Cardiology 2018

ISBN

—

ISSN

2325-887X

e-ISSN

—

Number of pages

4

Pages from-to

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Publisher name

IEEE

Place of publication

New York

Event location

Maastricht

Event date

Sep 23, 2018

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

000482598700281