Tapentadol in an Experimental Animal Model of Acute Orofacial Pain
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10391548" target="_blank" >RIV/00216208:11110/18:10391548 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/18:43917886
Result on the web
<a href="http://www.nel.edu/userfiles/articlesnew/1554982286_39_7_fricova_496-pdf.pdf" target="_blank" >http://www.nel.edu/userfiles/articlesnew/1554982286_39_7_fricova_496-pdf.pdf</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Tapentadol in an Experimental Animal Model of Acute Orofacial Pain
Original language description
OBJECTIVE: Tapentadol exhibits a synergistic dual effect effect (MOR / NRI) -agonist effect on noradrena-line reuptake inhibition (NRI). Tapentadol is effective on pain with neuropathic characteristics, therefore we decided to use it in an experimental model of acute orofacial pain. METHODS: The Orofacial Stimulation Test, developed by Ugo Basile, measures hypersensitivity to thermal or mechanical stimulation of the trigeminal area. In the experiment, rats had to voluntarily contact a thermal or mechanical stimulator with their unshaved vibrissal pad in order to access a food reward. Twenty adult laboratory rats (average weight 345 grams) were tested. Intraperitoneal tapentadol was used in doses of 1 mg/kg and 2 mg/kg. RESULTS: The results of the pilot study indicate that intraperitoneal administration of tapentadol (2 mg/kg) increased mechanical anti-nociception in rats.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/NV15-31538A" target="_blank" >NV15-31538A: Diagnostics and Therapy of Orofacial Pain</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neuroendocrinology Letters
ISSN
0172-780X
e-ISSN
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Volume of the periodical
39
Issue of the periodical within the volume
7
Country of publishing house
SE - SWEDEN
Number of pages
5
Pages from-to
496-500
UT code for WoS article
000462136800003
EID of the result in the Scopus database
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