Preemptive levetiracetam decreases postoperative pain in rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F08%3A00000922" target="_blank" >RIV/00216208:11120/08:00000922 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/08:4424
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Preemptive levetiracetam decreases postoperative pain in rats
Original language description
OBJECTIVES: Preemptive versus therapeutic effects of levetiracetam were investigated in a model of postoperative incisional pain in rats. METHODS: Levetiracetam (250, 500, and 1000 mg/kg intraperitoneal (i.p.) or morphine (5 mg/kg i.p.) was administeredeither 1 h before (preemptive administration) or 1 h after (therapeutic administration) incisional surgery to the hind paw of rats. The effects of levetiracetam were evaluated based on thermal hyperalgesia measured by the plantar test. RESULTS: All preoperatively treated levetiracetam groups showed a significant, dose dependent, increase in paw withdrawal latency. However, post-incisional administration of levetiracetam produced no antihyperalgesic effect at any dose or at any time. In contrast, post-incisional administration of morphine reduced thermal hyperalgesia, while preemptive administration of morphine did not produce any significant antihyperalgesic effects. CONCLUSION: The present results suggest that levetiracetam might posse
Czech name
Preemptivně podaný levetiracetam snižuje postooperační bolest u potkanů
Czech description
Na modelu termální hyperalgézie byla prokázána antihyperalgická účinnost levetiracetamu v případě preemptivního podání potkanům, kterým byla v anestezii provedena incize pravé zadní planty. V případě terapeutické (postoperační) aplikace se tento účinek neobjevil. Uvedené pozorování tedy svědčí pro možné preemptivně analgetické působení levetiracetamu.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NR9072" target="_blank" >NR9072: The role of neurotransmitters in mechanism of action of non-opioid analgesics</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neuroendocrinology Letters
ISSN
0172-780X
e-ISSN
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Volume of the periodical
29
Issue of the periodical within the volume
6
Country of publishing house
SE - SWEDEN
Number of pages
5
Pages from-to
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UT code for WoS article
000263044200024
EID of the result in the Scopus database
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