Ghrelin and endocannabinoids participation in morphine-induced effects in the rat nucleus accumbens
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F16%3A43910358" target="_blank" >RIV/00216208:11120/16:43910358 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s00213-015-4119-3" target="_blank" >http://dx.doi.org/10.1007/s00213-015-4119-3</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00213-015-4119-3" target="_blank" >10.1007/s00213-015-4119-3</a>
Alternative languages
Result language
angličtina
Original language name
Ghrelin and endocannabinoids participation in morphine-induced effects in the rat nucleus accumbens
Original language description
Rationale and objectives: In addition to dopamine, endocannabinoids are thought to participate in neural reward mechanisms of opioids. Number of recent studies suggests crucial involvement of ghrelin in some addictive drugs effects. Our previous resultsshowed that ghrelin participates in morphine-induced changes in the mesolimbic dopaminergic system associated with reward processing. The goal of the present study was to test whether the growth hormone secretagogue receptor (GHS-R1A) antagonist JMV2959was able to influence morphine-induced effects on anandamide (N-arachidonoylethanolamine, AEA) and 2-arachidonoylglycerol (2-AG) in the nucleus accumbens shell (NACSh). Methods: We used in vivo microdialysis to determine changes in levels of AEA and 2-AGin the NACSh in rats following (i) an acute morphine dose (5, 10 mg/kg s.c.) with and without JMV2959 pretreatment (3, 6 mg/kg i.p.) or (ii) a morphine challenge dose (5 mg/kg s.c.) with and without JMV2959 (3, 6 mg/kg i.p.) pretreatment
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT13687" target="_blank" >NT13687: The role of appetite regulating peptides in opioid and alcohol dependence.</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Psychopharmacology
ISSN
0033-3158
e-ISSN
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Volume of the periodical
223
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
16
Pages from-to
469-484
UT code for WoS article
000369247700011
EID of the result in the Scopus database
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