Ghrelin receptor antagonism of morphine-induced accumbens dopamine release and behavioral stimulation in rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F14%3A43897295" target="_blank" >RIV/60461373:22310/14:43897295 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s00213-014-3466-9" target="_blank" >http://dx.doi.org/10.1007/s00213-014-3466-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00213-014-3466-9" target="_blank" >10.1007/s00213-014-3466-9</a>

Result language

angličtina

Original language name

Ghrelin receptor antagonism of morphine-induced accumbens dopamine release and behavioral stimulation in rats

Original language description

Rationale and objectives Ghrelin, an orexigenic (appetite stimulating) peptide activates binding sites in the ventral tegmental area (a structure linked with the neural reward system) allowing it to participate in reward-seeking behavior. An increasing number of studies over the past few years have demonstrated ghrelin's role in alcohol, cocaine, and nicotine abuse. However, the role of ghrelin, in opioid effects, has rarely been examined. The aim of the present study was to ascertain whether a ghrelinantagonist (JMV2959) was able to inhibit markers of morphine-induced activation of the neural reward system, namely morphine-induced increase of dopamine in the nucleus accumbens and behavioral changes in rats. Methods We used in vivo microdialysis to determine changes of dopamine and its metabolites in the nucleus accumbens shell in rats following morphine (MO, 5, 10 mg/kg s.c.) administration with and without ghrelin antagonist pretreatment (JMV2959, 3, 6 mg/kg i.p., 20 min before MO).

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

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Project

<a href="/en/project/LO1215" target="_blank" >LO1215: Prague University Analytical Center for Health, Food Safety and Environmental Protection</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Psychopharmacology

ISSN

1432-2072

e-ISSN

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Volume of the periodical

231

Issue of the periodical within the volume

14

Country of publishing house

DE - GERMANY

Number of pages

10

Pages from-to

2899-2908

UT code for WoS article

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EID of the result in the Scopus database

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