Ghrelin receptor antagonism of morphine-induced accumbens dopamine release and behavioral stimulation in rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F14%3A43908039" target="_blank" >RIV/00216208:11120/14:43908039 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s00213-014-3466-9" target="_blank" >http://dx.doi.org/10.1007/s00213-014-3466-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00213-014-3466-9" target="_blank" >10.1007/s00213-014-3466-9</a>
Alternative languages
Result language
angličtina
Original language name
Ghrelin receptor antagonism of morphine-induced accumbens dopamine release and behavioral stimulation in rats
Original language description
Ghrelin, an orexigenic (appetite stimulating) peptide activates binding sites in the ventral tegmental area (a structure linked with the neural reward system) allowing it to participate in reward-seeking behavior. An increasing number of studies over thepast few years have demonstrated ghrelin?s role in alcohol, cocaine, and nicotine abuse. However, the role of ghrelin, in opioid effects, has rarely been examined. The aim of the present study was to ascertain whether a ghrelin antagonist (JMV2959) wasable to inhibit markers of morphine-induced activation of the neural reward system, namely morphine-induced increase of dopamine in the nucleus accumbens and behavioral changes in rats. Methods: We used in vivo microdialysis to determine changes of dopamine and its metabolites in the nucleus accumbens shell in rats following morphine (MO, 5, 10 mg/kg s.c.) administration with and without ghrelin antagonist pretreatment (JMV2959, 3, 6 mg/kg i.p., 20 min before MO). Induced behavioral chan
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT13687" target="_blank" >NT13687: The role of appetite regulating peptides in opioid and alcohol dependence.</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Psychopharmacology
ISSN
0033-3158
e-ISSN
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Volume of the periodical
231
Issue of the periodical within the volume
14
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
2899-2908
UT code for WoS article
000338634100016
EID of the result in the Scopus database
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