The Utilization of Cell-Penetrating Peptides in the Intracellular Delivery of Viral Nanoparticles
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F19%3A10397501" target="_blank" >RIV/00216208:11110/19:10397501 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/19:10397501
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ffwQTH6edh" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ffwQTH6edh</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ma12172671" target="_blank" >10.3390/ma12172671</a>
Alternative languages
Result language
angličtina
Original language name
The Utilization of Cell-Penetrating Peptides in the Intracellular Delivery of Viral Nanoparticles
Original language description
Viral particles (VPs) have evolved so as to efficiently enter target cells and to deliver their genetic material. The current state of knowledge allows us to use VPs in the field of biomedicine as nanoparticles that are safe, easy to manipulate, inherently biocompatible, biodegradable, and capable of transporting various cargoes into specific cells. Despite the fact that these virus-based nanoparticles constitute the most common vectors used in clinical practice, the need remains for further improvement in this area. The aim of this review is to discuss the potential for enhancing the efficiency and versatility of VPs via their functionalization with cell-penetrating peptides (CPPs), short peptides that are able to translocate across cellular membranes and to transport various substances with them. The review provides and describes various examples of and means of exploitation of CPPs in order to enhance the delivery of VPs into permissive cells and/or to allow them to enter a broad range of cell types. Moreover, it is possible that CPPs are capable of changing the immunogenic properties of VPs, which could lead to an improvement in their clinical application. The review also discusses strategies aimed at the modification of VPs by CPPs so as to create a useful cargo delivery tool.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10607 - Virology
Result continuities
Project
<a href="/en/project/GA17-11397S" target="_blank" >GA17-11397S: Study of the endocytotic machinery via modification of viral-based nanoparticles</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Materials
ISSN
1996-1944
e-ISSN
—
Volume of the periodical
12
Issue of the periodical within the volume
17
Country of publishing house
CH - SWITZERLAND
Number of pages
22
Pages from-to
2671
UT code for WoS article
000488880300024
EID of the result in the Scopus database
2-s2.0-85071866637