Unexpected therapeutic effects of cisplatin
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F19%3A10399989" target="_blank" >RIV/00216208:11110/19:10399989 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/19:00107805 RIV/00216305:26620/19:PU136078
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=lMRnK~-.hC" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=lMRnK~-.hC</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c9mt00049f" target="_blank" >10.1039/c9mt00049f</a>
Alternative languages
Result language
angličtina
Original language name
Unexpected therapeutic effects of cisplatin
Original language description
Cisplatin is a widely used chemotherapeutic agent that is clinically approved to fight both carcinomas and sarcomas. It has relatively high efficiency in treating ovarian cancers and metastatic testicular cancers. It is generally accepted that the major mechanism of cisplatin anti-cancer action is DNA damage. However, cisplatin is also effective in metastatic cancers and should, therefore, affect slow-cycling cancer stem cells in some way. In this review, we focused on the alternative effects of cisplatin that can support a good therapeutic response. First, attention was paid to the effects of cisplatin at the cellular level such as changes in intracellular pH and cellular mechanical properties. Alternative cellular targets of cisplatin, and the effects of cisplatin on cancer cell metabolism and ER stress were also discussed. Furthermore, the impacts of cisplatin on the tumor microenvironment and in the whole organism context were reviewed. In this review, we try to reveal possible causes of the unexpected effectiveness of this anti-cancer drug.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Metallomics : integrated biometal science
ISSN
1756-5901
e-ISSN
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Volume of the periodical
11
Issue of the periodical within the volume
7
Country of publishing house
GB - UNITED KINGDOM
Number of pages
18
Pages from-to
1182-1199
UT code for WoS article
000475799400011
EID of the result in the Scopus database
2-s2.0-85069179323