Snail defence responses to parasite infection: The Lymnaea stagnalis-Trichobilharzia szidati model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F20%3A10410524" target="_blank" >RIV/00216208:11110/20:10410524 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/20:10410524 RIV/00064165:_____/20:10410524
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Gjg.OB9J9" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Gjg.OB9J9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.dci.2019.103464" target="_blank" >10.1016/j.dci.2019.103464</a>
Alternative languages
Result language
angličtina
Original language name
Snail defence responses to parasite infection: The Lymnaea stagnalis-Trichobilharzia szidati model
Original language description
Lymnaea stagnalis is a common freshwater gastropod. Importantly, the snail serves as the intermediate host for more than one hundred species of digenetic trematodes, including the avian schistosome Trichobilharzia szidati, a causative agent of cercarial dermatitis in humans. Infection of L. stagnalis by T. szidati initiates a dynamic confrontation between the host and the parasite that culminates in immunocompatibility ensuring survival and development of larvae. Unfortunately, the molecular mechanisms determining this immunocompatibility remain poorly characterised. By employing a variety of immune elicitors, including chemical compounds, PAMPs and bacteria, research in the last two decades has elucidated some of the molecular processes that regulate the snail internal defence response such as haemocyte signalling pathways. These discoveries provide a framework for future studies of molecular interactions between T. szidati and L. stagnalis to help elucidate factors and mechanisms enabling transmission of schistosome parasites. Moreover, support from recently available next generation sequence data and CRISPR-enabled functional genomics should further enable L. stagnalis as an important model for comparative immunology and contribute to a more comprehensive understanding of immune functions in gastropod molluscs.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
<a href="/en/project/EF16_019%2F0000759" target="_blank" >EF16_019/0000759: Centre for research of pathogenicity and virulence of parasites</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Developmental and Comparative Immunology
ISSN
0145-305X
e-ISSN
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Volume of the periodical
102
Issue of the periodical within the volume
January
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
103464
UT code for WoS article
000491213900010
EID of the result in the Scopus database
2-s2.0-85072582731