Left ventricular apical pacing in children: feasibility and long-term effect on ventricular function
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F20%3A10410823" target="_blank" >RIV/00216208:11110/20:10410823 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/20:10410823 RIV/00064203:_____/20:10410823
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=91xcPk5J4C" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=91xcPk5J4C</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/europace/euz325" target="_blank" >10.1093/europace/euz325</a>
Alternative languages
Result language
angličtina
Original language name
Left ventricular apical pacing in children: feasibility and long-term effect on ventricular function
Original language description
Aims Left ventricular apical pacing (LVAP) has been reported to preserve left ventricular (LV) function in chronically paced children with complete atrioventricular block (CAVB). We sought to evaluate long-term feasibility of LVAP and the effect on LV mechanics and exercise capacity as compared to normal controls. Methods and results Thirty-six consecutive paediatric patients with CAVB and LVAP in the absence (N=22) or presence of repaired structural heart disease (N=14, systemic LV in all) and 25 age-matched normal controls were cross-sectionally studied after a median of 3.9 (interquartile range 2.1-6.8) years of pacing using echocardiography and exercise stress testing. Pacemaker implantation was uneventful and there was no death. Probability of the absence of pacemaker-related surgical revision (elective generator replacement excluded) was 89.0% at 5years after implantation. Left ventricular apical pacing patients had lower maximum oxygen uptake (P=0.009), no septal to lateral but significant apical to basal LV mechanical delay (P<0.001) which correlated with decreased LV contraction efficiency (P=0.001). Left ventricular ejection fraction and global longitudinal LV strain were, however, not different from controls. Results were similar in both the presence and absence of structural heart disease. Conclusion Left ventricular apical pacing is technically feasible with a low reintervention rate. Mechanical synchrony between LV septum and free wall is maintained at the price of an apical to basal mechanical delay associated with LV contraction inefficiency as compared to healthy controls. Global LV systolic function is, however, not negatively affected by LVAP.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Europace
ISSN
1099-5129
e-ISSN
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Volume of the periodical
22
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
306-313
UT code for WoS article
000515102900025
EID of the result in the Scopus database
2-s2.0-85079098092